Flashcards in 7 - Disorders of Male Reproduction Deck (13):
1
hormones produced by sertoli cells
anti mullerian hormone
inhibin and activin - regulate FSH secretion
estradiol - direct spermatogenesis
2
when does testosterone spike throughout lifetime?
fetal, neonatal, and puberty (long plateau after this one)
3
bioavailable testosterone includes both ___ & ___, but not ___
free and albumin bound
not SHBG bound
4
results of androgen def during 1st TM and 3rd TM
1st - genital ambiguity
3 - micropenis
5
results of androgen def before puberty
lack of male hair distribution
dec muscle mass / strength
diminished endurance
dec libido
infantile genitalia + prostate
eunuchoid skeleton (long legs and arms relative to body)
osteoporosis
high pitch voice
6
causes of primary testicular failure
Klinefelter's
orchitis
trauma
autoimmune damage
chemo / drugs (ketoconazole, spironolactone, alcohol)
cryptorchidism
LH receptor mutations
organ failure (liver, kidney)
7
genetic cause of tertiary testicular def
Kallman's syndrome - w/ assoc anosmia
8
hormone findings in androgen resistance syndromes
elevated gonadotropin and elevated testosterone (neg feedback on pituitary doesnt work b/c of mutation in receptor)
9
genetic disorder that makes genetic males have sort of a mixed / variable phenotype between normal male and female
5 alpha reductase def
10
drugs that can cause erectile dysfunction
CNS acting agents (anti depressants, methadone, cocaine, nicotine, etc)
anticholinergic
antiadrenergic
diuretics (thiazides)
antiandrogen
antihypertensive
11
peyronie's disease
chronic inflammation of tunica albuginea
causes pain, ED, and deformity
12
causes of non-physiologic gynecomastia
neoplasm - steroid or hCG producing, male breast CA
drugs - anti androgens, anti ulcer drugs, chemo, spironolactone, drugs of abuse, hormones, haloperidol
congenital - Klinefelter's, cryptorchidism, any dec testosterone state
testicular damage
systemic disorders - renal failure, liver failure, thyrotoxicosis
13