7 - Disorders of Male Reproduction Flashcards Preview

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Flashcards in 7 - Disorders of Male Reproduction Deck (13):
1

hormones produced by sertoli cells

anti mullerian hormone
inhibin and activin - regulate FSH secretion
estradiol - direct spermatogenesis

2

when does testosterone spike throughout lifetime?

fetal, neonatal, and puberty (long plateau after this one)

3

bioavailable testosterone includes both ___ & ___, but not ___

free and albumin bound
not SHBG bound

4

results of androgen def during 1st TM and 3rd TM

1st - genital ambiguity
3 - micropenis

5

results of androgen def before puberty

lack of male hair distribution
dec muscle mass / strength
diminished endurance
dec libido
infantile genitalia + prostate
eunuchoid skeleton (long legs and arms relative to body)
osteoporosis
high pitch voice

6

causes of primary testicular failure

Klinefelter's
orchitis
trauma
autoimmune damage
chemo / drugs (ketoconazole, spironolactone, alcohol)
cryptorchidism
LH receptor mutations
organ failure (liver, kidney)

7

genetic cause of tertiary testicular def

Kallman's syndrome - w/ assoc anosmia

8

hormone findings in androgen resistance syndromes

elevated gonadotropin and elevated testosterone (neg feedback on pituitary doesnt work b/c of mutation in receptor)

9

genetic disorder that makes genetic males have sort of a mixed / variable phenotype between normal male and female

5 alpha reductase def

10

drugs that can cause erectile dysfunction

CNS acting agents (anti depressants, methadone, cocaine, nicotine, etc)
anticholinergic
antiadrenergic
diuretics (thiazides)
antiandrogen
antihypertensive

11

peyronie's disease

chronic inflammation of tunica albuginea
causes pain, ED, and deformity

12

causes of non-physiologic gynecomastia

neoplasm - steroid or hCG producing, male breast CA
drugs - anti androgens, anti ulcer drugs, chemo, spironolactone, drugs of abuse, hormones, haloperidol
congenital - Klinefelter's, cryptorchidism, any dec testosterone state
testicular damage
systemic disorders - renal failure, liver failure, thyrotoxicosis

13

physiologic times for gynecomastia

neonate - circulating maternal hormones
puberty - while establishing balance between sex hormones
sensecence