(10) Clin Corr: EIC Flashcards Preview

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Flashcards in (10) Clin Corr: EIC Deck (13):
1

What happens during EIC?

- Can dogs die from this?

- hind limbs become weak, elevated rectal temperatures

- yes, but not often

2

What is a normal lab's temp after exercise? why so high?

What does this mean?

- 105 - 108

- no sweat glands

- dogs that get EIC really aren't any higher than normal dogs during exercise

3

Is EIC myasthenia gravis? What is myasthenia gravis? How do we know?

- no, antibodies against ACh receptors, dogs with EIC didn't have measureable AChR antibodies

4

Is it same mutation (RYR1) that causes malignant hyperthermia in dogs? 

What does this mutation cause in pigs?

- no

- porcine stress syndrome

5

Were there significant differences in blood chemistry, blood oxygen, EKG, and muscle pathology between normal dogs and dogs with EIC?

no

6

What gene was the EIC mutation found on?

Which gene specifically?

What was the specific nucleotide change?

Amino acid change?

- CFA9

- Dynamin 1

- G changed to T at 767

- codon 256 from arginine (basic/polar) to leucine (non-polar)

7

What does dynamin 1 do?

Where is it expressed?

What takes over for the lack of dynamin 1 doing its job?

- dynamin 1 is involved in vesicle recycling

- CNS, spinal cord

- dynamin 2 and 3 can pick up a bit of the slack - but not all of it

8

What's up with the shibire? What does it tell us about EIC?

- Shibire flies have all of their dynamin genes knocked out - they experience similar side afects when the temperature is raised - and then recover like dogs when it goes back down - this could indicate that EIC is temperature dependent

9

- Do dogs with EIC have progressive disease? Can they live normal lives?

What drug has been shown to work a little bit? How does it work? Does it target the problem directly?

- no, yes as long as they avoid prolonged physical activity

- phenobarbital, it works by decreasing level of excitement, does not address the issue directly

10

How is EIC different from heat stroke?

- heat stroke collapse takes hours to days for recovery, not the case with EIC!

11

How is the whole breeding problem being addressed?

- decrease carriers, but don't do it altogether - breed and replace

12

How is EIC tested?

- restriction fragment length polymorphism

13

What type of mutation is it?

- aautosomal recessive inheritance