#10. Stages of Tissue Healing Flashcards Preview

EPHE 344 > #10. Stages of Tissue Healing > Flashcards

Flashcards in #10. Stages of Tissue Healing Deck (46):
1

Primary Injury: blood and damaged tissue, pain and disability, and the body's initial reaction is inflammation. What is this?

Acute Macrotrauma

2

When the body induces inflammation, what is it trying to do?

create its own internal cast

3

Three major stages of healing?

1. Inflammatory Phase
2. Fibroblastic-Repair Phase (proliferation)
3. Maturation-Remodeling Phase

4

How long does the inflammatory phase last for?

72 hours to 4 days

5

How long does the Fibroblastic phase last for? When does this phase usually start?

3-4 weeks - starts around day 3 or 4 after injury

6

How long can the maturation phase last for and when does it usually begin?

up to a couple years; just because you cant see anything on the outside, doesnt mean it isnt trauma on the inside - starts around week 5ish after injury

7

During the inflammatory phase, when does healing begin?

immediately

8

Injury results in an altered _____ and liberation of various materials. What does this cause?

metabolism; when the metabolism is altered it makes the area very warm

9

The initial reaction to an injury is by the ____ and ____ cells.

leukocytes and phagocytic cells

10

The goal of the reaction by leukocytes and phagocytic cells is...?

-protect
-localize
-decrease injurious agents
-prepare for healing and repair

11

The inflammatory phase introduces ___, ____, and _____ responses that are all interwoven.

chemical, vascular, and cellular

12

What is the SHARP acronym? What is it used for?

S - swelling
H - heat
A - ache / ability to move?
R - redness
P - pain
Used for checking inflammatory response.

13

What does the RTCDF acronym stand for and what is it used for?

R - rubor (redness)
T - tumor (swelling)
C - color (heat)
D - dolor (pain)
F - functio laesa (loss of function)
Shitty acronym (doesn't form a word :/ ) used to check inflammatory response.

14

When a cell is injured, the chemical mediators are liberated, what are they? (3)

histamine, leukocytes, cytokines

15

When is the best time to see what is going on before swelling occurs?

The period of vasoconstriction that occurs before the vascular reaction of vasodilation.

16

After the vascular reaction occurs, ____ and ____ adhere to the vascular wall and _____ occurs which causes ____ formation.

Platelets and Leukocytes
Phagocytosis
Clot formation

17

____ _____ are derived from invading organisms, damaged tissue, plasma enzyme systems and WBCs

chemical mediators

18

Histamine is from what type of cell?

mast cells

19

___ is the first to arrive in an inflammatory response; it causes ____ and changes cell permeability owing to swelling

histamine ; vasodilation

20

What is margination and what chemical mediators impact it?

Adherence along cell walls - leukotrienes, bradykinin and prostaglandins

21

"increase permeability locally for fluid and protein passage"

diapedesis - done by leukotrienes, bradykinin and prostaglandins

22

Leukotrienes, bradykinin and prostaglandins facilitate exudate formation and ______ entrance to injured site.

neutrophil

23

____ regulate leukocyte and phagocytic activity

cytokines

24

7 Steps to Inflammatory Process?

1. Bacteria enters
2. Platelets release blood-clotting proteins @ wound site
3. Mast cells mediate vasodilation and vascular constriction
4. Neutrophils secrete factors that kill pathogens
5. Neutrophils/macrophages remove pathogens via phagocytosis
6. Macrophages secrete cytokines that attract immune cells
7. Response continues until all foreign bodies are gone

25

What is the vascular response?

-vasoconstriction and coagulation
-chemical mediators released
-vasodilation occurs 5-10 minutes later

26

When vasodilation occurs, initial increases in what are seen?

blood flow - transitory

27

When you have poor vascular flow, wear clothing that is too tight, or are on an airplane and get swollen feet what are you possibly experiencing?

Pitting edema

28

Clot formation - platelets adhere to exposed ____ leading to formation of a "plug"

collagen

29

Clots obstruct ______ drainage and aid in localizing injury

lymphatic - blocked drainage causes "swamp"

30

Clot formation requires the conversion of ____ to ____

fibrinogen to fibrin

31

The ___ clot seals the wound until the vessel wall heals.

fibrin

32

What is the final stage of the inflammatory phase?

when leukocytes phagocytize the remaining debris

33

What is it called when the acute inflammatory response is unable to eliminate the injuring agent?

Chronic Inflammation

34

____ inflammation is typically associated with overuse, overload, and cumulative microtrauma

chronic

35

What phase includes healing and regeneration?

II: fibroblastic repair

36

In what phase will athletes complain initially of pain with movement and point tenderness?

fibroblastic repair

37

During what phase do signs and symptoms of inflammation subside?

fibroblastic repair

38

During fibroblastic repair, capillary buds begin to _____

proliferate

39

what does it mean when capillaries proliferate?

they are reacting to hypoxia (lack of oxygen) by creating revascularization

40

Capillaries and fibroblasts unite and create a matrix that contains ____ and ____. This is the scar.

collagen and elastin

41

Tensile strength of the scar increase in proportion to _____ _____

collagen proliferation

42

What phase is characterized by a remodeling of the scar tissue according to tensile forces?

III: maturation and remodeling

43

____ Law - when you need to actually have pressure on it to have it heal

Wolfe's

44

___ has a limited capacity to heal due to the fact that it has little or no direct blood supply

Cartilage

45

If the injury is an an area of a synovial joint, why is it hard to heal?

The synovial fluid bathes all of the clotting away.

46

Full healing for a ligamentous injury may take up to how long?

12 months