Aspirin Flashcards
1
Q
Class
A
Antiplatelet
2
Q
Mechanism
A
- Non-selective, irreversible COX inhibition
- Decreased prostaglandin synthesis (PGI2, TxA2, Prostacyclin)
- Reduced platelet aggregation
3
Q
Indications
A
- Secondary prevention of MI & Stroke
4
Q
Interactions
A
- Non-selective NSAID, anticoagulants
N.B. Should NOT be taken with non-selective NSAID. Compete for COX-1 binding site on platelets
5
Q
SE
A
- GI irritation, ulceration/bleed
- Bronchospasm
6
Q
CI
A
- Asthma
- HTN
- Peptic ulcer
- Bleeding disorder
- Hypersensitivity
