Anti-Phospholipid Syndrome Flashcards

1
Q

pathogenesis

A

recurrent venous/arterial thrombosis, and/or foetal loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

who gets it?

A

some patients no associated symptoms

in other patients in association with SLE, or another AI disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what effect does it have?

A

increased frequency of stroke or MI (especially younger)
strokes secondary to in situ thrombosis
- embolization that originates from the valvular lesions of the Libman-Sacks (sterile) endocarditis (may be seen in patients with APS
recurrent PE/thrombosis - pulmonary hypertension
late spontaneous foetal loss (2nd/3rd trimester)
recurrent early foetal loss (10 weeks) also possible
migraine
livedo reticularis - common cutaneous finding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

how is it investigated?

A

thrombocytopenia
prolongation of APTT
immunology - lupus anticoagulant, anti-cardiolipin, anti-beta 2 glycoprotein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

how is it managed?

A

anti-coagulation for those with an episode of thrombosis
recurrent pregnancy loss - LMWH during pregnancy as warfarin is teratogenic
+ve antibodies without any episode of thrombosis previously - don’t require anti-coagulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly