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Microbiology And Immunology > Cell Mediated (II) > Flashcards

Cell Mediated (II) Flashcards

1
Q

What are MHC made of

A

Glycoproteins with domains

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2
Q

Which cells do MHC I activate

A

CD8 for intracellular / endogenous peptides

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3
Q

Which peptides do MHC II hold

A

Exogenous (endocytosed then cleaved by proteases)

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4
Q

Which 3 alleles of HLA genes encode for MHC I (3 a , 1 B2)

A

HLA - A,B,C

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5
Q

Which alleles encode for MHC II (2a,2b)

A

HLA - dp,dq,dr

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6
Q

Which chromosome holds HLA genes

A

16

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7
Q

Which cells is MHC 1 on

A

All nucleated cells (any virally infected can express them)

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8
Q

What makes MHC so polymorphic

A

Many alleles for the A chain

HLA A,B,C all have different a chains which make up the MHC 1

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9
Q

What is difference between MHC 1 peptide vs MHC 2

A

Shorter (8-10 AA long)

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10
Q

Which part of MHC 1 isn’t polymorphic

A

B2 micro globulin

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11
Q

How do A1,a2 on MHC 1 bind to 8-10 AA peptide

A

H bonds or ionic bonds

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12
Q

Which structure makes up the A1,A2 domains on MHC 1

A

2x beta sheets
2 x alpha helixes

(Highly polymorphic)

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13
Q

How is a3,B2 different to A1,a2

A

Ig like - only beta chains

Low polymorphisms

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14
Q

How long is polypeptide that A1,B1 bind to in MHC II

A

13-24 AA long (longer)

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15
Q

Where is the highest polymorphisms in MHC II of the dp,dq and dr alleles

A

A1, B1 (peptide cleft)

A2, B2 is ig like

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16
Q

What processes proteins made by viral cells which then make up MHC 1

A

Proteasome

17
Q

What transfers peptide fragments processed after proteasome to the ER (where MHC 1 lay)

A

TAP (in all nucleated cells)

18
Q

What covers the cleft (A1,B1) of MHC II before the endocytosed peptide can bind

A

Invariant chain

19
Q

Where do MHC II lay before the vesicles fuses with the peptide from proteases

A

ER and Golgi

20
Q

What is on T cells to allow for cell stimulation due to small cytoplasmic domain of tcr

A

Cd3 complex

21
Q

What 2 types of cd3 are there

A

Gamma epsilon

Gamma delta

22
Q

What does the CD3 have on it to allow signalling to T cell when T cell is bound with MHC

A

ITAMS

23
Q

What is CD8 and CD4

A

Gp needed to keep MHC close to T cell for activation

24
Q

What makes up CD8

A

Crossing of an alpha and beta

Interacts with MHC 1

25
Q

What makes up CD4 which interacts with MHC II

A

D1,2,3,4

26
Q

Why is polymorphisms of peptide cleft good

A

To allow broad range of peptide T cells can be activated by

27
Q

Why does polymorphisms in MHC cause graft rejection

A

Other persons HLA genes could be different so could be seen as foreign

28
Q

What is MHC expression induced by

A

IFN

29
Q

Why can a peptide be presented same time as another

A

MHC expression is codominant

Microbiology And Immunology (33 decks)

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