Hematopoietic Agents Flashcards

1
Q

Hematopoiesis

A

bodies make RBCs, WBCs, and platelets

Biologic name
Generic name
Brand name

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2
Q

Therapeutic applications:

Hematopoiesis

A

Acceleration of neutrophil and platelet repopulation after chemo

Acceleration of bone marrow recovery after an autologous bone marrow transplant

erythrocyte production in patients with chronic renal failure

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3
Q

Erythropoietic growth factors

A

stimulate the production of erythrocytes (RBCs); alt to blood transfusions; risk of stroke, heart failure, blood clots, MI, hypertension, and death

erythropoietin (Epoetin alpha): IV, subQ

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4
Q

Erythropoietic therapy to be effective

A

iron, folic acid, and vitamin B-12 levels need to be adequate.

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5
Q

Hematocrit

A

may take 2-4 wks to recover after administration of Erythropoietic therapy

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6
Q

erythropoietin (Epoetin alpha): IV, subQ

A

GRADUALLY raise hemoglobin

Increased risk of cardiac arrest, HTN, HF, and stroke/MI when patient hemoglobin is >11 gm/dL.

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7
Q

Leukopoietic Growth Factors

A

Stimulates the production of WBCs
Filgrastim

elevates neutrophil counts in cancer PT; apheresis collection; treat severe chronic neutropenia

reduce infection risk for chemo

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8
Q

Filgrastim

A

IV or subQ
Granulocyte colony-stimulating factor

Side effects:
BONE PAIN
Leukocytosis

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9
Q

Thrombopoietic Growth Factor

A

stimulate platelet production in patients undergoing myelosuppressive chemotherapy for nonmyeloid cancers

Oprelvekin

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10
Q

Oprelvekin

A

Administered SubQ

Should continue until platelet levels rise above 50,000/mm³

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11
Q

Oprelvekin side effects

A

Fluid retention/peripheral edema
Dyspnea (48% of patients)
Cardiac dysrhythmias
Anaphylaxis

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