Drugs for Hemophilia

Question 1

hemophilia

Answer 1

a genetic bleeding disorder is seen almost exclusively in males; platelets aggregate correctly, but fibrin formation does not

Question 2

Hemophilia A:

Answer 2

deficiency of clotting factor VIII (aka antihemophilic factor)

6x more prevalent

Question 3

Hemophilia B:

Answer 3

There is a deficiency of clotting factor IX (aka Christmas factor)

Question 4

Cornerstone of treatment is replacement therapy:

Answer 4

Factor VIII (for hemophilia A)
Factor IX (for hemophilia B)

based on prevention

Question 5

Desmopressin (for mild)

Answer 5

Promotes the release of factor VIII

Much cheaper than Factor VIII

med
Disadvantage: can deplete stored factor VIII

Question 6

Antifibrinolytic drugs:

Answer 6

Aminocaproic acid

Question 7

Pain meds:

Answer 7

Acetaminophen or opiates

Avoid NSAIDs and Aspirin

Question 8

Factor VIII-hemophilia A

Answer 8

Recombinant Factor VIII is safer than plasma-derived factor VIII (donor factor), but more expensive.

actual weight is needed to calculate dosage

Question 9

Factor VIII-hemophilia A

side effects

Answer 9

Hives, rash, stuffy nose, fever
GIVE ANTIHISTAMINE (diphenhydramine)

Question 10

Factor IX-hemophilia B

Answer 10

recombinant and donor forms available; Recombinant is safer; IV push at first signs of needs accurate weight

Question 11

Hemophilia Therapy-Desmopressin

Answer 11

Antidiuretic hormone

stop/prevent bleeding w/ mild depression; VIII for HA

Question 12

Hemophilia Therapy-Desmopressin side effects

Answer 12

Fluid retention

Hyponatremia