Pharmacokinetics

Question 1

Bioavailability factors

Answer 1

route of administration,drug enters the systemic circulation, conc appearing in the plasma is entered over time to say area under the curve

Question 2

Extraction or extraction ratio

Answer 2

fraction or percentage of drugs being removed from the perfusing blood during its passage through the organ

If it’s high, bioavailability is low

Question 3

dosage regimen

Answer 3

plan for drug administration so that therapeutic levels remain in the blood without exceeding the minimum toxic concentration
ideally used with knowledge of both therapeutic conc and minimum toxic concentrations

Question 4

Maintenance Dosage:

Answer 4

Because the maintenance rate=rate of elimination at a steady state

Question 5

Maintenance Dosage

Answer 5

bioavailability

Question 6

Loading Dose(if therapeutic concentration must be given rapidly)

Answer 6

Vd multiplied with desired concentration divided by bioavailability

Question 7

therapeutic window

Answer 7

safe range between between minimum therapeutic concentration and minimum toxic concentration

Question 8

theophylline

Answer 8

therapeutic concentration range of 8-20 mg/L but maybe toxic at concentration of more than 15-20 mg/L therapeutic window=8-16 mg/L

Question 9

Corrected Dosage

Answer 9

100 mL/min

Question 10

In elderly patients

Answer 10

72xScr