ANS Pharma ch 9 CHolinoceptor blockers Flashcards
1
Q
Antimuscarinic, nonselective
Atropine Competitive pharmaco- logic antagonist (inverse
agonist) at all M receptors
A
Mydriatic, cycloplegic •
antidote for cholinester-
ase inhibitor toxicity
2
Q
Antimuscarinic, selective
Darifenacin, fesoterodine,
solifenacin, tolterodine
Pirenzepine, telenzepine
A
Like atropine, but
modest selectivity for
M3 receptors
Significant M1 selectivity
Urinary urgency,
incontinence
Peptic disease (not
available in USA)
3
Q
Antinicotinic ganglion blockers
Hexamethonium Selective block of NN
receptors
A
Obsolete; was used for
hypertension
can also be given parenterally
Block of all autonomic
effects
4
Q
Pralidoxime
Chemical antagonist of
organophosphates
A
Organophosphate
poisoning
Parenteral
Muscle weakness
5
Q
All parasympatholytic effects
plus sedation, delirium,
hyperthermia, flushing
A
ATROPINE TOXICITY
