thrombolytics Flashcards
1
Q
endothelial cells also release
A
tissue plasminogen activator to aid in clot digestion so clotting cascade isn't crazy for coagulation (playset) alteplase reteplase tenecteplase
2
Q
other fibrinolytic agents
A
streptokinases
clinically lyses thrombolytics
3
Q
actual mechanism
A
both streptokinases and plasminogen(inactivator) will be raised
plasmin will generally degrade the clot
both the APTT and PT will be raised
D dimer is the product(evaluation for thrombosis,DVT)
4
Q
Ischemic Stroke
A
Black paint stroke
timely restoration of blood flow
iv fibrinolytic therapy
5
Q
acute MI,Acute broken heart strings
A
PCI therapy within 2 hrs
or fibrinolytic therapy
hemorrhagic stroke side effect,
6
Q
contraindications
A
recent head trauma,recent intracranial surgery,anaphylaxis in less than 0.5 pc
7
Q
what to use to reverse
A
aminocaproic acid.. paint on red tube competetively inhibits plasminogen activation
8
Q
FFp
A
coagulopathy reversal
