Lecture 12 Pathology Of Liver Flashcards
Steatosis
Fatty change in the liver
Steatohepatitis
Inflammation of the liver with a fatty change
Alcohol/ drug abuse
Accumulation of collagen (fibrosis) leads to decreased function of the liver and eventual cirrhosis
Caused by…
Diabetes, obesity, hyperlipidemia
Cirrhosis
Fibrous septa between the functional units of the liver, leading to ↓ function…
Partly caused by the regeneration of the liver
Portal triad and the central vein don’t have the same associations
Non alcoholic fatty liver disease (NAFLD)
Unexplained abnormal liver function Metabolic syndrome Usually metabolic syndromes cause cardiac deaths ————- Chronic low grade inflammation
Hepatitis A
Fecal oral transmission
Not chronic
Vaccine available
Hepatitis B
Blood, semen, vaginal fluid
Acute and chronic
Vaccine available
Hepatitis C
Chronic and acute
Blood, parental exposure
No vaccine
Hepatitis D
Acute and chronic
IV drug use, blood, parental exposure
Hep B vaccine helps, as it only replicates in the presence of hep B
Hepatitis E
Similar to A Acute only Fecal oral transmission Pork and shell fish spread Vaccine available
Autoimmune liver diseases
Autoimmune hepatitis
Sclerosing cholangitis
Primary biliary cirrhosis
Autoimmune hepatitis
Chronic hepatitis with rapid progression
- no positive serology
Associated w other autoimmune disease
Sclerosing cholangitis
Chronic inflammatory destruction of extra and intra hepatic bile ducts
Visible on MRI
Primary Biliary cirrhosis
Autoimmune destruction of bile ducts \
With normal radiology
Positive anti-mitochondrial autoantibodies
Causes of cirrhosis
Iron overload
Alcoholism
Hep B and C virus
Main cause for abnormal liver function tests
NAFLD
