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Tono Vascular > Losartán > Flashcards

Losartán Flashcards

1
Q

Mecanismo de acción

A

Antagonista del receptor AT1

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2
Q

Indicaciones clínicas

A

Nefropatía Diabética
Profilaxis de ictus
Insuficiencia cardiaca
Hipertensión portal “Renoprotector”

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3
Q

Farmacocinética relevante

A 
A: Oral
    F: 33% Reduce con comidas
D: 
    PB: 98.7%
    VD: 34L
M: Hepático CYP2C9 y CYP3A4
E: Renal/Hepático
    V1/2e: 2h
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4
Q

Reacciones adversas

A

Dolor de espalda
Mareo
Congestión Nasal

Falla renal aguda
Rabdomiolisis

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5
Q

Interacciones relevantes

A

IECAs

ARAs

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6
Q

Clasificación en el embarazo

A

C

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7
Q

Precauciones y contraindicaciones

A

Aliskiren (Inhibidor de la renina)

Puede producir Oligohidramnios
Lactancia incompatible

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Tono Vascular (12 decks)

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