11: transplantation 2 Flashcards Preview

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Flashcards in 11: transplantation 2 Deck (10):
1

3 types of transplantation after 6-hydroxydopamine

nigral tissue (promotes recovery of drug induced rotational beahviour, sensorimotor deficits). medullary chromaffin cells + polymer encapsulated PC12/GDNF producing cells (only partial recovery). mouse embryonic stem cells

2

MPTP model: changes? what transplantations?

loss of DA cells, along with beahvioural changes (tremor, freezing, mvt difficulty). transplantation of nigral tissue, medullary chromaffin cells + polymer encapsulated PC12 cells

3

adrenal medullary cell transplant in PD patients: results? after you place ___, results?

first clinical trials, autologous transplantation: minimal benefits. place grafts in contact with CSF: significant improvements in motor + cogn function

4

adrenal medullary cell transplant in PD patients: autopsy reports? overall, worth it or not?

few or no surviving cells within the graft. high mortality + morbidity outweigh modest improvements.

5

transplant embryonic ventral mesencephalic cells: what open studies aka? showed what?

open label studies aka no comparison to control: grafted DA-ergic neruons can survive, mature + alleviate tremors

6

transplant embryonic ventral mesencephalic cells: double blind RCT showed?

improvements for younger (

7

transplant embryonic ventral mesencephalic cells: survival of cells? outcome?

transplanted cells survived but dystonia + dyskinesias reccured after 1st year for 15% pts. limited benefits, despite good graft survival

8

fluorodopa uptake in PD pts w/ or w/o transplantation: results + meaning

uptake goes down after sham surgery, but uptake higher after transplantation = the transplanted neurons are surviving

9

fluorodopa uptake in PD : dose dependence?

more donors per side = more uptake. still, overtime you see a decrease in uptake = still have degeneration

10

autopsy after transplantation: what you see?

immunological reactions : microglia. maybe this is what impairs the behavioural improvements