Flashcards in 4: normal aging 3 Deck (14):
if LTP is a neural analogue of learning/memory then: learning should elicit? artificial LTP should?
learning should elicit an LTP-like change in the brain. artificial LTP should interfere with normal learning/induce false memories.
if LTP is a neural analogue of learning/memory then: saturation of LTP should? blockade of LTP should? reversal of LTP should?
saturation: prevent learning, interfere with previous memories. blockade: prevent learning, won't interfere with previous memories. reversal: erase previous memories
if LTP is a neural analogue of learning/memory then: aging effects on LTP?
should parallel aging effects on hippocampal dependent, spatial, learning and memory tasks
cells which show increased firing rates when animal is in a specific location
place fields: formation? stabilitiy? depends on? aged rats?
formation is rapid, requires experience to become stable. NMDA-R dependent (LTP like process maybe). Aged rats have unstable place fields
place fields are locked to?
geographical features. ex: rotate cylinder with spatial cues, the place cell firing rotates too
place cells are specific?
context/environment specific. ex: circular vs. triangular environments
place fields and stability?
place fields exhibit stability in the same environments. ex: recording over days/weeks, the existing place field is stable
elderly rats and place field experiment
unstable place fields in elderly rats across (but not within) sessions in given environment
place fields and goals?
4 arm radial maze: place field activity corresponds to rat's selected goal arm
when rats travel repeatedly on given path, what happens to place fields? reflects?
place fields expand: could reflect an LTP-like association between sequentially activated place cells, might be a network mechanism for stable place field formation
place field expansion: what direction? depends on? older rats?
always in the direction opposite to travel (aka backwards). NMDA-R dependent. older rats show less place field expansion
summary: main changes in physiology (2) and plasticity (2) with aging
decreased synaptic response, calcium dysregulation which lead to impaired LTP and enhanced LTD