1.10 RBC Metabolism

Question 1

Total blood volume

Answer 1

5-6 liters

Question 2

Whole blood minus the formed elements

Answer 2

Plasma

Question 3

Whole blood minus formed elements and clotting factors

Answer 3

Serum

Question 4

Normal RBC count for ment

Answer 4

5-6 million/mm3

Question 5

Normal RBC count for women

Answer 5

4-5 million/mm3

Question 6

Normal life span of RBCs

Answer 6

90-120 days

Question 7

Controls RBC production

Answer 7

Erythropoietin by the kidneys

Question 8

Ankyrin binds to integral protein ___

Answer 8

Band 3

Question 9

Actin binds to peripheral protein ___

Answer 9

Band 4.1

Question 10

integral protein important for anion exchange

Answer 10

Band 3

Question 11

Proteins that help shape and allow flexibility of the RBC

Answer 11

Peripheral proteins

Question 12

Gives the cell membrane its strength and flexibility

Answer 12

Spectrin

Question 13

RBC membrane transporter that is insulin dependent

Answer 13

GLUT-1

Question 14

The A antigen in blood type A has an extra ___

Answer 14

GalNAc

Question 15

The B antingen in blood type B has an extra __

Answer 15

Gal

Question 16

RBC metabolism of glucose via anaerobic glycolysis

Answer 16

Embden-Meyerhoff Pathway

Question 17

RBC metabolism of glucose via Pentose Phosphate Pathway; aerobic

Answer 17

Hexose Monophosphate Shunt

Question 18

Enzyme responsible for the conversion of phosphoenolpyruvate to pyruvate is ___

Answer 18

Pyruvate kinase

Question 19

Enzyme responsible for the conversion of Pyruvate to lactate is ___

Answer 19

L-lactate dehydrogenase

Question 20

Enzyme responsible in converting G6P to 6-phosphogluconate then to ribulose 5-phosphate

Answer 20

G6P dehydrogenase

Question 21

Enzyme responsible for converting 1,3 diphosphoglycerate to 2-3 diphosphoglycerate

Answer 21

diphosphoglycerate mutase

Question 22

Enzyme responsible for converting 2,3-DPG to 3 phosphoglycerate

Answer 22

2,3 BPG phosphatase

Question 23

RBC disorder due to abnormalities in spectrin

Answer 23

Hereditary elliptocytosis

Question 24

A genetic defect caused partial or total absence by one or more alpha or beta chains of hemoglobin

Answer 24

Thalassemia

Question 25

Heme is the prosthetic group of ___ in the liver

Answer 25

Cytochrome p450

Question 26

rate controlling enzyme in heme biosynthesis

Answer 26

Ala synthase

Question 27

Steps and enzymes in heme biosynthesis

Answer 27

Enzymes:ALA synthaseALA dehydrataseHMB synthaseUroporphyrinogen III synthaseUroporphyrinogen decarboxylaseCoproporphyrinogen oxidaseProtoporphyrinogen oxidaseFerrochelatase

Question 28

Group of disorders caused by abnormalities in the pathway of biosynthesis of heme

Answer 28

Porphyria

Question 29

Also known as bone marrow failure where the body doesnt make enough RBCs, WBCs, and platelets

Answer 29

Aplastic anemia

Question 30

Hemoglobinopathy with increased concentration of erythrocytes

Answer 30

Polycythemia vera

Question 31

Hemoglobinopathy characterized by large cells with increased nuclear/cytoplasmic ratio

Answer 31

Megaloblastic enmia

Question 32

Hemoglobinopathy characterized by small and pale red blood cells due to iron deficiency

Answer 32

Vitamin B6 or iron-deficiency anemia