3.2 Lipid Digestion And Absoprtion Flashcards
(31 cards)
Stomach digestion of lipids is catalyzed by
Lingual lipase
Gastric lipase
Digestion of lipids starts in the
Stomach
Gastric lipase removes fatty acids located at
Carbon 1 and 3
Product of gastric lipase
2-monoacylglycerol
Site of lipid emulsification
Duodenum
Produces bile salts
Liver
Stores bile salts
Gall bladder
Cholesterol derivatives consist of a
Sterol ring with glycine or taurine
Are emulsifying agents which stabilize the dietary lipid particles as they become smaller and prevent them from coalescing
Bile salts
Acts upon TAG molecules which are too large to be taken up efficiently by mucosal cells of the intestinal villi
Pancreatic lipase
Pancreatic lipase removes acids at carbon ___ using __ reactions
1 and 3
Hydrolysis
Products of hydrolysis by pancreatic lipase
2-monoacylglycerol and free fatty acids
Restores activity to lipase in the presence of inhibitory substances like bile acids that bind the micelles
Colipase
Orlistat inhibits
Gastric lipase and pancreatic lipase
Hydrolyzes cholesteryl esters to produce free cholesterol plus free fatty acids
Cholesteryl Ester Hydrolase (Cholesterol Esterase)
Increases the activity of cholesteryl ester hydrolase (cholesteryl esterase)
Bile salts
COntained in the pancreatic juice which removes one fatty acid from carbon 2 of a phospholipid
Phospholipase A2
product of a phospholipase A2
Lysophospholipid
Removes remaining fatty acid at carbon 1 of a phospholipid
Lysophosphplipase
Product of a lysophospholipase
Glycerolphosphoryl base
Small peptide hormone produced by the cells in the mucosa of lower duodenum and jejunum; formed in response to the presence of lipids and partially digested proteins entering the duodenum and jejunum
Cholecystokinin
Functions of the cholecystokinin
Gallbladder: enables release of bile
Pancreatic: exocrine cells: release of digestive enzymes
Decrease gastric motility
Small peptide hormone produced by the intestines in response to the low pH of the chyme entering the pH; causes the pancreas and the liver to release a solution rich in bicarbonate to neutralize pH to enhance digestive activity by pancreatic enzymes
Secretin
Site of bile absorption
Ileum