Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Biochemistry > 1.6 Immunity and Complement > Flashcards

1.6 Immunity and Complement Flashcards

(60 cards)

Start Studying
1
Q

Pathogen for tlr1-2

A

Fungi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Pathogen for tlrs 3,7,8

A

Viruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Pathogen for tlr 4

A

Gram + bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Pathogen for tlrs 5,9,10

A

Bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cytokines shared by both innate and adaptive immunity

A

IL 4, IL 6, and INF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Ig best at opsonization

A

IgG1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Ig best at sensitization by mast cells

A

IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Ig best at activation of complement system

A

IgM and IgG3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Ig that can transport through epithelium

A

IgA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Ig that can transport through placenta

A

IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Ig that cannot diffuse into extravascular sites

A

IgD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Major Ig in serum

A

IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Agglutinating IgEfficient in leading the lysis of microorganismsFirst to be made by fetus virgin b cells after stimulation by an antigen

A

IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

2nd most common serum IgIn secretions, including colostrum

A

IgA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Ig primarily found in B cell surfacesFunctions as receptor for antigensHas extra amino acids at c terminal which anchors to membranesDoes not bind complement

A

IgD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Least common serum IgInvolved in allergic reactionsPlay a role in parasitic helminthsDoes not fix complement

A

IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Ig mediator for immediate hypersensitivity

A

IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Ig mediator for antibidy-mediated hyperaensitivity

A

IgG and IgM and complement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Ig mediator for immune complex-mediated hypersensitivity

A

IgG and complement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Ig mediator for delayed sensitivity

A

T cells, macrophages, histiocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Functions to activate cells including-innate immune system-b lymphocytes-cytotoxic t cells-nonimmune cellsCritical role in suppression of immune reaction

A

Cd4+ t cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Function of cd4+ helper t cells

A

Secrete cytokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

CD4+ helper t subsets that functions to secrete cytokines thatSuppress tumor immunityPromotes immune toleranceMaintains lymphocyte homeostasis

A

TregTGF-BIL-10IL-35STAT6FOXP3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

CD4+ helper t subsets that functions to secrete cytokines thatPromotes tumor immunityIntracellular pathogens immunityDrives autoimmunity

A

Th1IFB-yLTaSTAT4T-bet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
CD4+ helper t subsets that functions to secrete cytokines thatMediates allergy, asthma, and extracellular immunity
Th2IL-4IL-5IL-13STAT6GATA3
26
CD4+ helper t subsets that functions to secrete cytokines thatMediate controversial tumor immunityBreaks immune toleranceFight extracellular bacteriaAutoimmunuty
Th17
27
Function of CD8+ T cells
Kill infected cells containing cytoplasmic microbes
28
Phases of CD8+ T cells action
Recognition of MHC-I associated peptide antigensDegranulation of CTLsRelease of perforinsPerforins activate caspasesApoptosis
29
Key component of the C4b2a (c3 convertase) complex
C4
30
Serine proteinase which activates factor b
Factor D
31
Stabilizes the C3bBb complex
Properdin
32
Key component for both amplification step generation if C5 convertase activity
c3
33
Components of the membrane attack complex
C5-9
34
First component of the MAC
C5
35
Binds C5b and C7 in the MAC
C6
36
Binds c7 and c8 in the MAC
C7
37
Binds c8 and c9
C8
38
Polymerises to firm large membrane pore
C9
39
Initiators of the classical complement pathway
Immune complexesApoptotic cellsCertain viruses and gram(-) bacteriaC-reactive protein bound to ligand
40
Initiator of mannose-binding lectin pathway
Microbes with terminal mannose groups
41
Initiator of alternative complement pathway
Many bacteria, fungi, viruses, and tumor cells
42
Effector function of c5a and C3a
InflammationRecruitment and activation of leukocytesDestruction of microbes by leukocytes
43
Effector function of c3b
Phagocytosis
44
Effector function of MAC
Lysis of microbe
45
First cell type to arrive at the injury site
Neutrophils
46
Oxidative burst machinery
NETs or neutrophil extracellular traps
47
Cytokine that stimulates eosinophil development and differentiation
IL-5
48
Release proinflammatory mediatora
Eosinophils
49
Ensures that distinct antigens elicit responses that target those antigens
Specificity
50
Enables immune system to respond to a large variety of antigens
Diversity
51
Leads to rapid and enhanced responses to repeated exposures to the same antigens
Memory
52
Increases number of antigen-specific lymphocytes to keep pace with microbes
Clonal expansion
53
Generates responses that are optimal for defense against different types of microbes
Specialization
54
Precursor of tissue macrophages
Neutrophils
55
Heterogenous group of immunicompetent cells that mediate the cellular immune response by processing and presneting antigens ti the t cells.
APCs
56
Transmembrane proteins that revignize invading microbes and activate signaling pahtways that kaunch immune and inflammatory responses to destroy the invaders
Toll-like receptors
57
Pathogen for tlr 2-6
Gram + bacteriaFungiMycobacteria
58
Major Ig in serum and extracellular spaces; most abundant among newborns; predominant antibody in secondary response
IgG
59
Agglutinating Ig and complement fixing Ig; lysis of microorganisms; first produced by naive B cells in primary immune response; J chain
IgM
60
2nd most common Ig in serum
IgA

Biochemistry (29 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions