Myeloproliferative disorders

Question 1

What are the three types of myeloproliferative disorder?

Answer 1

Remember these as “PPE”:

• Primary myelofibrosis
• Polycythaemia vera
• Essential thrombocythemia

Question 2

Myeloproliferative disorders have the potential to progress and transform into which type of leukaemia?

Answer 2

AML

Question 3

Myeloproliferative disorders are associated with which genetic mutation?

Answer 3

JAK2

Question 4

Which complication is common in both polycythaemia vera and essential thrombocythemia?

What medical treatment is used to reduce the risk of this complication?

Answer 4

Thrombosis

Aspirin

Question 5

What are the typical findings on FBC in:

a) Polycythaemia vera
b) Essential thrombocythemia
c) Primary myelofibrosis

Answer 5

a) Raised Hb
b) Raised platelets
c) Anaemia (WCC and platelets may be high or low)

Question 6

Which sign may be present on abdominal examination in patients with myeloproliferative disorders?

Answer 6

Hepatosplenomegaly

Question 7

What systemic symptoms might be present in a patient with a myeloproliferative disorder?

Answer 7

Fever
Weight loss
Night sweats

Question 8

What is the diagnostic investigation for the myeloproliferative disorders?

Answer 8

Bone marrow biopsy

Question 9

Myelofibrosis is considered a type of bone marrow cancer… True or false?

Answer 9

True

Question 10

A blood film in myelofibrosis may show … shaped RBCs

Answer 10

Teardrop-shaped RBCs