Translation

Question 1

Streptomycin & Other Aminoglycosides

Answer 1

Binds to the 30S subunit, distorting it’s structure, Prevents binding of fMet-tRNA to the P site of ribosomes, Inhibits Initiation; Includes gentamicin, amikacin, tobramycin, netilmicin & neomycin

Question 2

Tetracyclines

Answer 2

Prevents interaction of 30S ribosomal subunit with aminoacyl-tRNA, thereby preventing the binding of the tRNA’s to the A-site and inhibiting elongation of the peptide chain

Question 3

Cycloheximide

Answer 3

Inhibits 60S subunit in eukaryotes & inhibits peptidyl transferase activity, thereby prevents peptide bond formation, prevents elongation

Question 4

Erythromycin & Clindamycin

Answer 4

Binds to the 50S ribosome
Blocks aminoacyl translocation by EF-G Preventing elongation; effective against gram-positive bacteria & spirochaetes but not against gram-negative organisms (except H. influenzae, Mycoplasma pneumoniae & legionella species).

Question 5

Puromycin

Answer 5

aminoacyl-tRNA; premature chain termination

Question 6

Diphteria toxin; Rx: high dose NAD

Answer 6

eEF-2; inhibits translocation; Respiratory tract infection

Question 7

Atazanavir

Answer 7

Protease; inhibits cleavage and activation of viral structural proteins