Nature of Cancer & Oncogenes Flashcards
1
Q
Primary vs Metastasis?
A
Primary:
Localised to orginating organ
Metastatic (secondary):
Colonisation in distant organs but derived from cells of primary tumour
2
Q
Benign Tumours
A
Local without invading adjacent tissues
3
Q
Malignant Tumours
A
Invading adjacent tissues or seeded metastases
4
Q
Most common type of tissue for tumours?
A
Epithelial tissues-
SCC from epithelia that protect underlying tissue
Adenocarcinoma from mucus secreting epithelia
5
Q
Tumour morphology progression sequence
A
Normal Hyperplastic Metaplastic Dysplastic Neoplasm Malignant Neoplasm
6
Q
What are proto-oncogenes
A
Normal genes that can become oncogenes due to mutation or altred expression
7
Q
Pathways to oncogene generation
A
Viral transcriptional promoters can drive very high levels of expression (Myc)
Single base pair (point) mutation (H-ras)
