Heterolytic chemistry

Question 1

what is a heterocycle

Answer 1

a cyclic compound with one or moren on c atom in it

Question 2

what do heterolytic drugs have good potential for

Answer 2

interacting with binding sites in enzymes

the main ones being hydrogen bond donors and hydrogen bond acceptors

Question 3

what are heterolytic drugs useful for

Answer 3

lead compounds

probe structure activity relationship

Question 4

when is a ring aromatic

Answer 4

it has 4n + 2 pi electrons

electrons are fully conjugated

it is planar

Question 5

what does knowledge of the aromatic nature of these molecules allow us to predict

Answer 5

reactivities and devise appropriate synthesis of lead compounds and libraries of compounds

Question 6

for pyridine what rule is followed

Answer 6

huckels ruleq

Question 7

what is huckels rule

Answer 7

Hückel’s rule predicts that a planar ring molecule will have aromatic properties if it has 4n + 2 π electrons, where n is a non-negative integer

Question 8

is pyridine nucleophilic

Answer 8

yes due to the ability of it to react with other binding site due to its electrons

Question 9

what is the difference between benzene and pyridine

Answer 9

slight change from perfect hexagonal geometry due to the presence of heteroatom (shorter cn bond)

the replacement of hydrogen in the plane of the ring with an unshared electron pair not involved with the pi electron aromatic sextet

a strong permanent dipole dipole owing to greater electronegativity of N

Question 10

is pyradine basic or acidic

Answer 10

basic

Question 11

is pyridine a nucleophile or an electrophile

Answer 11

nucleophile

Question 12

what cannot be made using reactions of pyridine with electrophiles

Answer 12

pyridine compounds with subsituents on the carbon atoms

Question 13

at what positions do pyridine react readily with nucelophiles

Answer 13

2 and 4

Question 14

in reactions with pyridine and nucleophiles what happens regarding aromaticity

Answer 14

restored at the end of the reaction