Histopathology 2: Neoplastic Bone Disorders

Question 1

X-ray: Codman’s Triangle at end of long bones
Histology: Malignant mesenchymal cells

Diagnosis?

Answer 1

Osteosarcoma

Question 2

X-ray: Lytic lesions with fluffy calcification
Histology: Malignant chondrocytes

Diagnosis?

Answer 2

Chondrosarcoma

Question 3

X-ray: Onion skinning of periosteum
Histology: Sheets of small round cells
Karyotype: shows t(11;22)

Diagnosis ?

Answer 3

Ewing’s sarcoma

Question 4

X-ray: Lytic appearance in the epiphysis of knee
Histology: Giant cells look like osteoclasts, spindle/ovoid cells

Diagnosis?

Answer 4

Giant cell tumour

Question 5

X-ray: Soap bubble osteolysis, Shepherd’s crook deformity
Histology: Chinese letters

Diagnosis ?
Associated syndrome ?

Answer 5

Fibrocystic dysplasia

Albright syndrome

Question 6

List the triad of features Albright syndrome?

Answer 6

• Polyostotic dysplasia
• cafe au lait spots
• Precocious puberty

Question 7

X-ray: Mushroom protuberance from Bone
Histology: Cartilage capped bony outgrowth

Diagnosis?

Answer 7

Osteochondroma

Question 8

X-ray: popcorn calcification
Histology: Proliferation of cartilage

Diagnosis ?

Answer 8

Enchondroma

Question 9

X-ray: Bulls eye appearance of radioleucent nidus with sclerotic rim
Histology: normal bone arising from osteoblasts

Diagnosis ?

Answer 9

Osteoid Osteoma

Question 10

Which benign bone tumour causes pain at night which is relieved by Aspirin ?

Answer 10

Osteoid osteoma

Question 11

In which syndrome do you get Osteomas, GI polyps and epidermoid cysts ?

Answer 11

Gardner syndrome

Question 12

Which bone tumour shows speckles mineralisation and is similar to osteoid osteoma ?

Answer 12

Osteoblastoma