Microbio: Antimicrobials 2 Flashcards

1
Q

What are the different indications for using B-lactam abx?

A

Gram +ve

Gram -ve: 3rd gen cephalosporins, carbapenems

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2
Q

What are the different indications for using glycopeptide (eg. vancomycin) abx?

A

MRSA, C. diff

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3
Q

What are the indications for using amnioglycoside abx? (eg gentamicin)

A

Gram –ve sepsis

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4
Q

What are the indications for using tetracycline abx? (eg doxycycline)

A

Intracellular (chlamydia)

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5
Q

What are the indications for using macrolide abx? (eg erythromycin)

A

Gram +ve (penicillin allergy), atypical pneumonia

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6
Q

What are the indications for using chloramphenicol abx? (eg Eye drops)

A

Bacterial conjunctivitis

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7
Q

What are the indications for using oxazolidinone abx? (eg Linezolid)

A

Gram +ve, MRSA, VRE

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8
Q

What are the indications for using fluroquinolones abx? (eg ciprofloxacin)

A

Gram -ve

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9
Q

What are the indications for using nitoimidazole abx? (eg metronidazole)

A

Anaerobes, protozoa, C. diff

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10
Q

What are the indications for using rifamycin abx? (eg rifampicin)

A

Mycobacteria (TB)

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11
Q

What are the indications for using sulfonamide abx? (eg sulphamethoxazole)

A

PCP (sulphamethoxazole with trimethoprim = co-trimoxazole)

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12
Q

What are the indications for using diaminopyrimidine abx? (eg trimethoprim)

A

UTI

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13
Q

What abx is generally given to skin infections (usually s. aureus)?

A

Flucloxacillin

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14
Q

What abx is generally given to pharyngitis?

A

Benzylpenicillin

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15
Q

What abx is generally given to CAPs?

A

Mild: amoxicillin
Severe: co-amoxiclav
Atypical: clarithromycin

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16
Q

What abx is generally given to HAPs?

A

Co-amoxiclav + Gentamicin / Tazocin

17
Q

What abx is generally given to bacterial meningitis?

A

Ceftriaxone

+ ampicillin if young/old

18
Q

What abx is generally given to UTIs?

A

Trimethoprim / nitrofurantoin / cephalexin / co-amoxiclav

19
Q

What abx is generally given to C. diff colitis?

A

Metronidazole

Vancomycin (2nd line)

20
Q

Which of the following is the most appropriate antibiotic choice to treat cellulitis?

a) Benzylpenicillin
b) Co-amoxiclav
c) Flucloxicillin 
d) Meropenem
e) Clarithromycin
A

c) Flucloxicillin - skin infection most likely s. aureus

21
Q

A patient has a mild (CURB 1) pneumonia. You would usually prescribe amoxicillin, however the patient is penicillin allergic. Which of the following is the most appropriate alternative?

a) Co-amoxiclav
b) Ceftriaxone
c) Meropenem 
d) Clarithromycin
e) Ciprofloxacin
A

d) Clarithromycin

22
Q

A stool sample sent for a patient with diarrhoea is positive for C. diff toxin. Which of the following is the most appropriate antibiotic choice?

a) Metronidazole
b) Meropenem
c) Ciprofloxacin
d) Gentamycin
e) Rifampicin
A

a) Metronidazole