AFRICAN SLEEPING SICKENSS

Question 1

Vector

Answer 1

tsetse fly

Question 2

species

Answer 2

t. b rhodiesence

t. b gambiense

Question 3

distribution

Answer 3

east africa- rhodiescenc

central.west gambiense

Question 4

which one is more common

Answer 4

gambiense

Question 5

which one has a chronic course

Answer 5

gambiense

Question 6

which one is a zoonose

Answer 6

rhodisence + chagas disease

Question 7

what do we call the disease in animals

Answer 7

nagana

Question 8

who can transmit the infection

Answer 8

tse tse (f+m)

Question 9

stages of african sleeping

Answer 9

1. cutanouse
2. hemolymphatic stage
3. Cns stage

Question 10

what manifest in cutaneous stage

Answer 10

a chancre at the site, painful red , seen usually with rhodisecne

Question 11

winterbottom’s sign

Answer 11

gambiense, posterior cervical ln painless

Question 12

which african has more lymphadenopathy

Answer 12

gambiense

Question 13

forms of parasite african and where found

Answer 13

1. trypomastigote - bloodm lymph, organs

2. epimastigote - salivary glands of vector

Question 14

diagnosis of african

Answer 14

always need to check csf to see if spread to decide treatment,

blood - works more rhodes
LN aspirate - gambiense
culture - weinman’s medium

Question 15

classic tx african

Answer 15

1. pentamidine
2. eflornithine
3. suramin
4. melarsoprol

Question 16

which other disease do we use pentamidine

Answer 16

pneumocystis + visceral leishmaniasis

Question 17

agent of chagas

Answer 17

t. cruzi

Question 18

vector

Answer 18

reduviid bug - kissing bug - night time bugs unlike tse tse

Question 19

IP for chagas disease

Answer 19

1-2 weeks

Question 20

what forms are found in humans in chagas disease

Answer 20

amastigotes - inside

extracellular - trypomastigotes

Question 21

how do humans get infected by chagas disease

Answer 21

not by the bite but mythe bug defecting when it feeds

Question 22

infective form in chagas disease

Answer 22

metacyclic trypomastigotes

Question 23

classic features of chagas disease

Answer 23

ramonas signs- entry site conjunctiva

chagoma

Question 24

stages of chagas

Answer 24

acute - usually childhood + self limiting

intermediate - serologic evidence but no physical symptoms

chronic - cardiac and gastrointestinal, megacolon and megaly

Question 25

diagnosis of chagas

Answer 25

bloods (high parasitemia) in ACUTE
serological - more chronic
thin + thick prepartions

Question 26

if you did a blood test for chagas disease what would u find

Answer 26

trypomastigotes

Question 27

treatment of chagas

Answer 27

nifurtimox- high toxicity
benznidazole
but if already chronic drugs cannot reverse