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Path questions imperialendo.co.uk > Lipoproteins > Flashcards

Lipoproteins Flashcards

1
Q

Choose the most appropriate answer from the list

  • Short-chain-CoA dehydrogenase (SCAD) deficiency
  • Long-chain-CoA dehydrogenase (LCAD) deficiency
  • Medium-chain-CoA dehydrogenase (MCAD) deficiency
  • Very long-chain-CoA dehydrogenase (MCAD) deficiency
  • Familial hypertriglyceridaemia I
  • Diabetes mellitus
  • Familial hypertriglyceridaemia IV
  • Hypothyroidism
  • Familial hypertriglyceridaemia V
  • Gout
  • Familial hypercholesterolaemia II
  • Tangier disease
  • Polygenic hypercholesterolaemia
  • Hypo-a-lipoproteinaemia
  • Familial hyper-a-lipoproteinaemia
  • Ab-lipoproteinaemia

The most common cause in the Western world for secondary hyperlipidaemia.

A

Diabetes mellitus

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2
Q

Choose the most appropriate answer from the list

  • Short-chain-CoA dehydrogenase (SCAD) deficiency
  • Long-chain-CoA dehydrogenase (LCAD) deficiency
  • Medium-chain-CoA dehydrogenase (MCAD) deficiency
  • Very long-chain-CoA dehydrogenase (MCAD) deficiency
  • Familial hypertriglyceridaemia I
  • Diabetes mellitus
  • Familial hypertriglyceridaemia IV
  • Hypothyroidism
  • Familial hypertriglyceridaemia V
  • Gout
  • Familial hypercholesterolaemia II
  • Tangier disease
  • Polygenic hypercholesterolaemia
  • Hypo-a-lipoproteinaemia
  • Familial hyper-a-lipoproteinaemia
  • Ab-lipoproteinaemia

There is high-density lipoprotein (HDL) deficiency as a result of ABC AI mutations.

A

Tangier disease

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3
Q

Choose the most appropriate answer from the list

  • Short-chain-CoA dehydrogenase (SCAD) deficiency
  • Long-chain-CoA dehydrogenase (LCAD) deficiency
  • Medium-chain-CoA dehydrogenase (MCAD) deficiency
  • Very long-chain-CoA dehydrogenase (MCAD) deficiency
  • Familial hypertriglyceridaemia I
  • Diabetes mellitus
  • Familial hypertriglyceridaemia IV
  • Hypothyroidism
  • Familial hypertriglyceridaemia V
  • Gout
  • Familial hypercholesterolaemia II
  • Tangier disease
  • Polygenic hypercholesterolaemia
  • Hypo-a-lipoproteinaemia
  • Familial hyper-a-lipoproteinaemia
  • Ab-lipoproteinaemia

This inborn error of metabolism is tested for universally, across the United Kingdom a few days after birth.

A

Medium-chain-CoA dehydrogenase (MCAD) deficiency

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4
Q

Choose the most appropriate answer from the list

  • Short-chain-CoA dehydrogenase (SCAD) deficiency
  • Long-chain-CoA dehydrogenase (LCAD) deficiency
  • Medium-chain-CoA dehydrogenase (MCAD) deficiency
  • Very long-chain-CoA dehydrogenase (MCAD) deficiency
  • Familial hypertriglyceridaemia I
  • Diabetes mellitus
  • Familial hypertriglyceridaemia IV
  • Hypothyroidism
  • Familial hypertriglyceridaemia V
  • Gout
  • Familial hypercholesterolaemia II
  • Tangier disease
  • Polygenic hypercholesterolaemia
  • Hypo-a-lipoproteinaemia
  • Familial hyper-a-lipoproteinaemia
  • Ab-lipoproteinaemia

A form of inherited disease that causes high levels of VLDL and chylomicrons in the plasma. It is sometimes due to apoA V deficiency.

A

Familial hypertriglyceridaemia V

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5
Q

Choose the most appropriate answer from the list

  • Short-chain-CoA dehydrogenase (SCAD) deficiency
  • Long-chain-CoA dehydrogenase (LCAD) deficiency
  • Medium-chain-CoA dehydrogenase (MCAD) deficiency
  • Very long-chain-CoA dehydrogenase (MCAD) deficiency
  • Familial hypertriglyceridaemia I
  • Diabetes mellitus
  • Familial hypertriglyceridaemia IV
  • Hypothyroidism
  • Familial hypertriglyceridaemia V
  • Gout
  • Familial hypercholesterolaemia II
  • Tangier disease
  • Polygenic hypercholesterolaemia
  • Hypo-a-lipoproteinaemia
  • Familial hyper-a-lipoproteinaemia
  • Ab-lipoproteinaemia

Autosomal dominant mutations, usually of the LDL-receptor, and is associated with tendon xanthoma, arcus senilis cornea and xanthelasma palpebarum.

A

Very long-chain-CoA dehydrogenase (MCAD) deficiency

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6
Q

Choose the most appropriate answer from the list

  • Abeta-lipoproteinaemia
  • Familial hypertriglyceridaemia (Type I)
  • Alzheimer’s Disease
  • Familial hypertriglyceridaemia (Type IV)
  • Atherosclerosis
  • Familial hypertriglyceridaemia (Type V)
  • Cerebrotendinous xanthomatosis
  • Hypoalpha-lipoproteinaemia
  • Familial combined hyperlipidaemia
  • Hypobeta-lipoproteinaemia
  • Familial dysbetalipoproteinaemia (type III)
  • Phytosterolaemia
  • Familial hepatic lipase deficiency
  • Polygenic hypercholesterolaemia
  • Familial hypercholesterolaemia (type II)
  • Tangier disease

Patient with this disease possesses the homozygous isoform of ApoE, ApoE2/E2

A

Familial dysbetalipoproteinaemia (type III)

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7
Q

Choose the most appropriate answer from the list

  • Abeta-lipoproteinaemia
  • Familial hypertriglyceridaemia (Type I)
  • Alzheimer’s Disease
  • Familial hypertriglyceridaemia (Type IV)
  • Atherosclerosis
  • Familial hypertriglyceridaemia (Type V)
  • Cerebrotendinous xanthomatosis
  • Hypoalpha-lipoproteinaemia
  • Familial combined hyperlipidaemia
  • Hypobeta-lipoproteinaemia
  • Familial dysbetalipoproteinaemia (type III)
  • Phytosterolaemia
  • Familial hepatic lipase deficiency
  • Polygenic hypercholesterolaemia
  • Familial hypercholesterolaemia (type II)
  • Tangier disease

A type of primary hypercholesterolaemia which involves the mutation of ATP-binding cassette (ABC) transporters G5 and G8

A

Phytosterolaemia

ABC G5 & G8 usually act to prevent absorption of plant sterols

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8
Q

Choose the most appropriate answer from the list

  • Abeta-lipoproteinaemia
  • Familial hypertriglyceridaemia (Type I)
  • Alzheimer’s Disease
  • Familial hypertriglyceridaemia (Type IV)
  • Atherosclerosis
  • Familial hypertriglyceridaemia (Type V)
  • Cerebrotendinous xanthomatosis
  • Hypoalpha-lipoproteinaemia
  • Familial combined hyperlipidaemia
  • Hypobeta-lipoproteinaemia
  • Familial dysbetalipoproteinaemia (type III)
  • Phytosterolaemia
  • Familial hepatic lipase deficiency
  • Polygenic hypercholesterolaemia
  • Familial hypercholesterolaemia (type II)
  • Tangier disease

An autosomal dominant form of primary hypercholesterolaemia which can be caused by the gain of function mutation of proprotein convertase subtilisi/kexin type 9 (PCSK9) gene

A

Familial hypercholesterolaemia (type II)

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9
Q

Choose the most appropriate answer from the list

  • Abeta-lipoproteinaemia
  • Familial hypertriglyceridaemia (Type I)
  • Alzheimer’s Disease
  • Familial hypertriglyceridaemia (Type IV)
  • Atherosclerosis
  • Familial hypertriglyceridaemia (Type V)
  • Cerebrotendinous xanthomatosis
  • Hypoalpha-lipoproteinaemia
  • Familial combined hyperlipidaemia
  • Hypobeta-lipoproteinaemia
  • Familial dysbetalipoproteinaemia (type III)
  • Phytosterolaemia
  • Familial hepatic lipase deficiency
  • Polygenic hypercholesterolaemia
  • Familial hypercholesterolaemia (type II)
  • Tangier disease

Autosomal dominant mutation of the ApoB gene could lead to this condition

A

Hypobeta-lipoproteinaemia

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10
Q

Choose the most appropriate answer from the list

  • Abeta-lipoproteinaemia
  • Familial hypertriglyceridaemia (Type I)
  • Alzheimer’s Disease
  • Familial hypertriglyceridaemia (Type IV)
  • Atherosclerosis
  • Familial hypertriglyceridaemia (Type V)
  • Cerebrotendinous xanthomatosis
  • Hypoalpha-lipoproteinaemia
  • Familial combined hyperlipidaemia
  • Hypobeta-lipoproteinaemia
  • Familial dysbetalipoproteinaemia (type III)
  • Phytosterolaemia
  • Familial hepatic lipase deficiency
  • Polygenic hypercholesterolaemia
  • Familial hypercholesterolaemia (type II)
  • Tangier disease

A condition resulted from dysregulated lipoprotein metabolism leading to cholesterol deposition in the arterial wall

A

Atherosclerosis

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11
Q

Choose the most appropriate answer from the list

  • Apo A1
  • PCSK9
  • Apo B
  • Apo C
  • Apo D
  • Apo E
  • CETP
  • HMG-CoA Reductase
  • LDLRAP1

Is found in VLDL and chylomicrons, and activates lipoprotein lipase in the capillaries

A

Apo C

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12
Q

Choose the most appropriate answer from the list

  • Apo A1
  • PCSK9
  • Apo B
  • Apo C
  • Apo D
  • Apo E
  • CETP
  • HMG-CoA Reductase
  • LDLRAP1

Is the main apolipoprotein of LDL and chylomicrons, leading to heart disease if deficient

A

Apo B

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13
Q

Choose the most appropriate answer from the list

  • Apo A1
  • PCSK9
  • Apo B
  • Apo C
  • Apo D
  • Apo E
  • CETP
  • HMG-CoA Reductase
  • LDLRAP1

Binds to LDL receptor to promote degradation, loss of function of which leads to low LDL levels

A

PCSK9

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14
Q

Choose the most appropriate answer from the list

  • Apo A1
  • PCSK9
  • Apo B
  • Apo C
  • Apo D
  • Apo E
  • CETP
  • HMG-CoA Reductase
  • LDLRAP1

Class of apolipoprotein that is produced by astrocytes in the CNS, polymorphisms of which are associated with Parkinsons’ and Alzheimer’s Disease

A

Apo E

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15
Q

Choose the most appropriate answer from the list

  • Apo A1
  • PCSK9
  • Apo B
  • Apo C
  • Apo D
  • Apo E
  • CETP
  • HMG-CoA Reductase
  • LDLRAP1

Major factor of High Density Lipoprotein, mutation of which can lead to a paradoxical drop in HDL concentration and a reduction in atheroma in animal models

A

Apo A1

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Path questions imperialendo.co.uk (44 decks)

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