Apoptosis and Necrosis

Question 1

What is Apoptosis

Answer 1

Non inflammatory natural cell death

Question 2

What is Necrosis

Answer 2

Inflammatory traumatic cell death

Question 3

Describe the cell characteristics in apoptosis

Answer 3

Cells = shrink
Organelles = Retained
Cytoplasm = Intact
Chromatin = Unchanged
Easy phagocytosis due to fragmentation

Question 4

Describe the cell characteristics of Necrosis

Answer 4

Cells= burst
Organelles = Spilled
Cytoplasm = Damaged
Chromatin = Changed
Fucked up cell

Question 5

What are the three mechanisms of apoptosis

Answer 5

Intrinsic (Bax)
Extrinsic (Fas L)
Cytotoxic (CD8+)

Question 6

What is the Intrinsic mechanism of apoptosis

Answer 6

Bax acts on mitochondrial membrane = Cytochrome C release = Activate caspases = Apoptosis

Question 7

What is Bax inhibited by

Answer 7

BCL-2

Question 8

What is the Extrinsic mechanism of Apoptosis

Answer 8

FasL/TNF-L binds to cytoplasm receptors = Activate caspases = Apoptosis

Question 9

What is the Cytotoxic mechanism of Apoptosis

Answer 9

CD8+ Binding = Granzyme B release = Perforin = Activate caspases = Apoptosis

Question 10

What does CD8+ Binding release in cytotoxic apoptosis

Answer 10

Granzyme B -> Perforin

Question 11

Which A apoptosis mechanism releases granzyme B and perforin

Answer 11

Cytotoxic Apotosis

Question 12

What are the 4 types of necrosis

Answer 12

Coagulative (Organ ischemia)
Liquefactive (Liquid brains)
Caseous (Soft cheese in TB)
Gangrene (Black -deposited fe from Hb)