hypersensitivity

Question 1

type I hypersensitivity

Answer 1

immediate hypersensitivity

allergic reaction from reexposure

Question 2

type I hypersensitivity def

Answer 2

exaggerated immune response that causes tissue damage and can kill

Question 3

reqs for type i

Answer 3

contact with allergen
priming/sensitizing dose
ige production
reexposure

Question 4

what are results of hypersensitivity I ?

Answer 4

epi damage
edema
SM spasms
leukocyte infiltration 
mucus secretion

Question 5

what IG mediates type I?

Answer 5

igE

Question 6

in type I what takes up the allergen

Answer 6

APC

Question 7

Th2 release ___ which is required for what?

Answer 7

IL4 required for isotope switching to IgE

Question 8

what are the preformed mediators in type I granules?

Answer 8

histamine
heparin (proteoglycan)
tryptase chemise and cathepsin
serotonin

Question 9

histamine roles

Answer 9

constricts SM, intestine and brinchioles

vasodilation –> fluid to tissue –> mucosal swelling

Question 10

what are the newly formed mediators of type I?

Answer 10

leukotrienes
Th2 cytokines
thromboxane
platelet activation factor

Question 11

what does type I cause in the GIT?>

Answer 11

diarrhea
vomitting
cramping

Question 12

what does type I cause in the skin?

Answer 12

urticaria
angioedema
itching

Question 13

what does type I cause in the airway?

Answer 13

wheezing
sneezing
asthma
rhinitis

Question 14

type I causes systemic vasodilation and SM muscle contraction resulting in what?

Answer 14

bronchiole constriction
edema
shock

Question 15

type ii hypersenstiivity aka

Answer 15

cytotoxic antibody hypersensitivity

Question 16

type ii involves which immunoglobulins ?

Answer 16

Igm and igg

Question 17

examples of type ii

Answer 17

transfusion of RBCs and hemolytic disease in newborns

Question 18

type iii aka ( 2)

Answer 18

immune complex formation and ag-ab immune complexes igg mediated

Question 19

what normally removes immune complex ?

Answer 19

mononuclear phagocytes system

Question 20

what is chemotactic for neutrophils and a mast cell activator?

Answer 20

C5a

Question 21

how long does it take for a type iii hypersensitivity to occur?

Answer 21

4-8 hours

Question 22

immune complex mediated disease

Answer 22

persistent infections
autoimmune disease
inhalation of antigenic material

Question 23

what persistent infections of immune complex mediated diseases?

Answer 23

malaria
viral hepatitis
subacute endocarditis
glomerulonephritis

Question 24

what autoimmune diseases of immune complex mediated diseases?

Answer 24

SLE
RA
Polymyositis

Question 25

what inhalation of antigenic materials of immune complex mediated diseases? ( I know q doesn’t make sense I don’t feel like coming up with something that does )

Answer 25

farmers lung

pigeon fanciers lung

Question 26

type iv hypersenstiivity aka

Answer 26

cell mediated / delayed

Question 27

when does type iv arise?

Answer 27

24-72 hours after exposure

Question 28

types of type iv

Answer 28

contact dermatitis
tuberculin rxn
granulomatous rxn

Question 29

type iv lesion characterized by?

Answer 29

induration and erythema

Question 30

what cell ivovled in type iv>

Answer 30

th1

Question 31

examples of type I aka anaphylactic

Answer 31

allergic asthma

hay fever

Question 32

examples of type ii aka cytotoxic

Answer 32

erythroblastosis
fetalis
goodpasture’s nephritis

Question 33

examples of type iii aka immune complex

Answer 33

see farmers lung disease

Question 34

examples of type iv aka delayed

Answer 34

tuberculin
poison ivy
granuloma