FA Vankomicinas, linezolidas Flashcards
Vancomycin binds to …
terminal D-alanine–D-alanine in bacterial pentapeptide peptidoglycan subunits
Once vancomycin binds what happens?
prevents transpeptidase from binding to the pentapeptide, thereby inhibiting cell wall cross-linking
What changes are in species resistant to vancomycin?
Resistance stems primarily from substitution of the terminal D-alanine with D-lactate, which prevents vancomycin binding.
vanco Bactericidal or static?
Bactericidal - against most bacteria
static - agains cl.difficile
in resistance D-alanine is substituted to what?
D-lactate
What is prevented from binding in vancomycin use?
prevents transpeptidase from binding to the pentapeptide
Vancomycin resistance mechanisms? 2
Mutated peptidoglycan cell wall;
impaired influx/increased efflux
kaip duodamas vankomicins?
letai i/v (neabsorbuojamas is VT)
vankomicino salinimas?
beveik nemetabolicuojamas, salinamas per inkstus
vancomycin relation to beta-lactamases?
Not susceptible to beta-lactamases.
vancomycin for what gram bugs?
only gram +
in general in what cases used vancomysin?
serious, multi-drug resistant m/o, including MRSA, S. epidermidis, sensitive Enterococcus spp., cl.difficile (oral dose for pseudomembranous colitis)
when vancomycin is given p/o?
cl.difficile (oral dose for pseudomembranous colitis)
adverse vanco?
nephrotoxicity (renal failure), ototoxicity, thrombophlebitis, red man syndrome, dress syndrome
Oxazolidinones agent?
Linezolid
