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1 STEP Microbiology > FA 1st and 2n cephalosporins > Flashcards

FA 1st and 2n cephalosporins Flashcards

1
Q

1st generation agents? 2

A

cefazolin and cephalexin

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2
Q

2nd generation agents? 4

A

cefaclor, cefoxitin, cefuroxime, cefotetan

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3
Q

cefazolin generation?

A

1st generation

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4
Q

cephalexin generetion?

A

1st generation

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5
Q

cefaclor generation?

A

2nd generation

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6
Q

cefoxitin generation?

A

2nd generation

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7
Q

cefuroxime generation?

A

2nd generation

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8
Q

cefotetan generation?

A

2nd generation

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9
Q

1st generation cover what?

A

gram + cocci; proteus mirabilis; e coli; klebsiella pneumonia.

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10
Q

cefazolin used when?

A

i/v; prior to surgery to prevent S aureus wound infection.

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11
Q

kodel 1st generation netinkama meningitui?

A

does not cross BBB

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12
Q

1st generation and renal function?

A

in renal failure - netinkami

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13
Q

1st generation on pseudomonas?

A

does not cover

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14
Q

1st generation spektras?

A

siauras

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15
Q

2nd generation cover what?

A

gram +, h influenza, enterobacte aerogenes, neisseria spp., Serratia marcescens, Proteus mirabilis, klebsiella pneumonia

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16
Q

2nd generation and renal function?

A

in renal failure - netinkami

17
Q

2nd generation on pseudomonas?

A

does not cover

18
Q

kodel 2nd generation netinkama meningitui?

A

does not cross BBB

19
Q

cephalexin administration?

A

p/os

20
Q

cefazolin administration?

A

im, iv

21
Q

cefaclor administration?

A

p/os

22
Q

cefuroxime administration?

A

p/os, i/v

23
Q

cefoxitin administration?

A

i/v

24
Q

cefotetan administration?

A

i/v

25
Q

which generation is more effective against gram + cocci?

A

1st stronger than 2nd

26
Q

adverse of all cephalosporins?

A

hypersensitivity, autoimmune hemolytic anemia;
disulfiram-like reaction; vit K def; Low rate of cross-reactivity ee in penicillin-allergic patients; Increase nephrotoxicity of aminoglycosides.

27
Q

cephalosporins mechanism of resistance?

A

inactivated by cephalosporinases (a type of beta-lactamase); Structural change in penicillin binding proteins (transpeptidases).

1 STEP Microbiology (20 decks)

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