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1 STEP Microbiology > viruses general classification DNA > Flashcards

viruses general classification DNA Flashcards

1
Q

Which DNA is ss?

A

Parvoviridae

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2
Q

Which DNA are circular? 3

A

Polyomaviridae, papillomaviridae, hepadnaviridae

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3
Q

Parvoviridae what virus?

A

DNA ss, naked

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4
Q

which DNA is complex (all other are icosahedral)?

A

Poxviridae

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5
Q

Which DNA virus replicates in cytoplasm?

A

Poxviridae

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6
Q

Poxviridae where replicates?

A

in cytoplasm

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7
Q

where replicates all DNA viruses except poxviridae?

A

in nucleus

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8
Q

Polyomaviridae, papillomaviridae, hepadnaviridae nucleic. acid form?

A

circular

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9
Q

what DNA are naked?4

A

parvo, polyoma, papilloma, adenovirus

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10
Q

what DNA are enveloped? 2

A

hepadnaviridae, herpesviridae
FA kad ir poxvirus, bet UW - kad complex coat.

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11
Q

Parvoviridae?

A

DNA, icosahedral, naked, ss

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12
Q

Polyomaviridae?

A

DNA, icosahedral, naked, ds circular

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13
Q

Papillomaviridae?

A

DNA, icosahedral, naked, ds circular

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14
Q

Adenovirus?

A

DNA, icosahedral, naked, ds

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15
Q

Hepadnaviridae?

A

DNA, icosahedral, enveloped, ds circular

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16
Q

Herpesviridae?

A

DNA, icosahedral, enveloped, ds

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17
Q

Poxviridae?

A

DNA, complex, complex coat, ds, replicates in cytoplasm

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18
Q

Herpes virus. types

A

HSV1 ir HSV2

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19
Q

HSV1 diseases?

A

gingivostomatitis, keratoconjuctivitis, herpes labialis, HERPETIC WHITLOW ON FINGER (in dentists especially), TEMPORAL LOBE ENCEPHALITIS, esophagitis, erythema multiforme

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20
Q

HSV1. How spread virus to cause temporal encephalitis?

A

down the olfactory tract -> olfactory cortex in temporal lobe.

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21
Q

HSV1. where latent?

A

in trigeminal ganglia

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22
Q

HSV1. Brain?

A

Most common cause of sporadic encephalitis. Present as altered mental status, seizures, and/or aphasia.

23
Q

HSV2. diseases?

A

Herpes genitalis, neonatal herpes.

24
Q

HSV2. Latent where?

A

In sacral ganglia.

25
Q

HSV1 transmission?

A

respiratory secretions, saliva

26
Q

HSV2 transmission?

A

sexual contact, perinatal

27
Q

Which DNA virus is the largest?

A

Poxvirus

28
Q

Poxvirus diseases?

A

Varicella zoster (chirckenpox, shingles), encephalitis, pneumonia.

29
Q

Varicela hoster virus name?

A

HHV3

30
Q

What cause reactivation of HHV3?

A

age, trauma, malignancy, immunosupression

31
Q

Most common complication of shingles?

A

post-herpetic neuralgia

32
Q

HHV3 latent?

A

In dorsal root of cutaneous sensory neuron OR trigeminal ganglia.
CN V1 branch -> herpes zoster ophthalmicus.

33
Q

HHV3 transmision?

A

Resp secretions, contact with fluid from vesicles.

34
Q

Epstein bar virus (HHV4). diseases?

A

Mononucleosis

35
Q

mononucleosis presentation?

A

fever, hepatosplenomegaly, pharyngitis, lymphadenopathy (esp. posterior cervical nodes).

36
Q

Epstein bar virus (HHV4). assoc with what 3 malignancies?

A

Endemic (aka african) burkitt limphoma; nasopharyngeal carcionoma (esp. asian adults), lymphoproliferative diease in transplant patients.

37
Q

Epstein bar virus (HHV4) infects B cell throught?

A

CD21

38
Q

Epstein bar virus (HHV4). what test positive?

A

Positive monospost test - heterophile antibodies detected by agglutination of sheep or horse RBCs.

39
Q

Epstein bar virus (HHV4). transmission?

A

resp. secretions, saliva (aka kissing disease)

40
Q

Cytomegalus virus (HHV5). transmission?

A

CONGENITAL, transfusion, sexual contact, saliva, urine, transplant

41
Q

Cytomegalus virus (HHV5). monospot test?

A

negative (in comparison to EBV).

42
Q

Cytomegalus virus (HHV5). diseases?

A

mononucleosis (monospot negative) in IMMUNOCOMPETENT;
Infection in immunocompromised - pneumonia in transplant;
esophagitis; AIDS;
RETHINITIS - hemorrhage, cotton-wool exudates, vision loss.

CONGENITAL CMV

43
Q

Cytomegalus virus (HHV5). On biopsy?

A

Infected cells have characteristic ,,owl eye” intraNUCLEAR inclusions

44
Q

HHV6-7. transmission?

A

saliva

45
Q

HHV6-7. disease?

A

Roseola infantum (exanthem subitum): high fevers for several days that can cause seizures, followed by diffuse macular rash (trunk -> to extremities).

46
Q

HHV8. Transmission?

A

sexual contact

47
Q

HHV8. disease?

A

Kaposi sarcoma (neoplasm of ENDOTHELIAL cells)

48
Q

HHV8. in what patients?

A

HIV/AIDS and transplant patients

49
Q

Pox virus what skin disease?

A

Molluscum contagiosum

50
Q

Hepadnavirus - what disease?

A

HBV -> acute or chronic hepatitis
Not a retrovirus, but has reverse transcriptase

51
Q

Adenovirus - 6 diseases?

A

Febrile pharyngitis - sore throat
Acute hemorrhagic cystitis
Pneumonia
Conjuctivitis ,, pink eye”
Gastroenteritis
Myocarditis

52
Q

Papillomavirus - disease?

A

HPV warts - 1,2,6, 11
CIN 16, 18

53
Q

Polyomavirus - diseases?

A

JC virus - progressive multifocal leukoencephalopathy in HIV
BK virus - transplant patients, commonly targets kidney

54
Q

Parvovirus ->?

A

B19 - aplastic crises in sicle cell disease,, slapped cheek rash in kids (erythema infectosom or fifth disease”
Infects RBC precursors and endothelial cells

RBC destruction leads to pure RBC aplasia and RA-like symptoms

1 STEP Microbiology (20 decks)

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