Ibuprofen

Question 1

What is ibuprofen?

Answer 1

Ibuprofen (200mg tablet) is a non-selective NSAID that inhibits the synthesis of prostaglandins resulting in analgesic, antipyretic & anti-inflammatory actions.

Onset - 15 mins
Duration - 4 to 6 hours
Half-life - 2 hours

Metabolised by the liver and excreted by the kidneys.

Question 2

Indications for ibuprofen?

Answer 2

1. Moderate pain due to acute inflammation & tissue injury

Question 3

Contraindications for ibuprofen?

Answer 3

1. Allergy/ADR to any NSAID or aspirin
2. Concurrent NSAID therapy
3. Current GI bleeding or peptic ulcers
4. Dehydration and or hypovolaemia
5. Renal impairment
6. NSAID induced asthma
7. Heart failure
8. Pregnancy
9. Angiotensin converting enzyme (ACE) inhibitors or angiotensin II receptor blocker (ARB) therapy
10. Patients under 13 yrs or over 65 yrs
11. Patients taking anticoagulant medications
12. Diuretic treatment

Question 4

Precautions for ibuprofen?

Answer 4

1. Asthma
2. Hepatic dysfunction
3. History of GI bleeding or peptic ulcers

Question 5

Side effects of ibuprofen?

Answer 5

1. Nausea
2. Dyspepsia
3. GI bleeding
4. Dizziness

Question 6

What is the ibuprofen dose for an adult?

Answer 6

200-400mg PO

Must not be administered within 6 hours of previous ibuprofen administration