Breast Flashcards

1
Q

What to think of when asymettric breasts are mentioned in Q?

A

Asymmetic breast can be completely normal

Abnormalitis that cause shrunken breast and therefore asymmetry include Invasive lobular breast cancer

-if size difference is NEW or breast parenchyma is asymettrically dense = think cancer

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2
Q

Breast calcifications

A

If there are** linear or segmental calcifications** that pass along a duct = this is suspicious for malignancy

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3
Q

What is main blood supply to breast?

Where is lymphatic drainage?

A

60% is from internal mammary artery

The other is from lateral thoracic and intercostal vessels

Lymph drainage is 97% to the axilla (last 3% is to internal mammary)

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4
Q

How many types of nodes are present in breast?

Where are they located?

Where are Rotter nodes located?

A

There are 3 types

Level 1: Lateral to pec minor

Level 2: Deep to pec minor

Level 3: Medial and above pec minor

Rotter Nodes: located between pec major and pec minor

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5
Q

What is Sternalis muscle?

A

Accessory muscle of the chest

Not everyone has it

It can be mistaken for a breast mass on CC views

Should not biopsy

How to tell if it is a mass or not?

It will only be visible on CC views not MLO

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6
Q

Where is the most common area for ectopic breast tissue?

A

Axillary is most common

Next is inframammary fold

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7
Q

High yield trivia

A
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8
Q

What is a galactocele and how does it appear?

A

A benign fat containing and milk containing lesion

Usually seen after cessation of lactation
Basically a retention cyst seen after occlusion of lactiferous duct

Usually subareolar
-fat fluid level is buzzword

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9
Q

What are lactating adenomas?

A

Usually appear as multiple masses that look like Fibroademonas in women who are breastfeeding

Can regress after you stop lactation

Followup in 4 - 6 months post partum

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10
Q

In what cases might you use a LMO view instead of MLO?

A

Patients with kyphosis or pectus excavatum

Or to avoid central line or pacemaker

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11
Q

ML vs LM

Which parts of breast are shown better in each view?

A

ML shows lateral breast in better detail

LM shows medial breast in better detail

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12
Q

Does mammography always use a grid?

A

Yes but not on Magnification views

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13
Q

How to localise a single lesion on the MLO view

A

Muffins Rise
Lead Sinks

If lesion is medial on CC view it will be at top on true lateral

If lesion is lateral on CC view if will be on bottom of true lateral

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14
Q

How to localise a lesion only seen on the CC view?

A

Do rolled views

If breast is rolled medially from the top = superior lesion will appear more MEDIAL
inferior lesion will appear more LATERAL

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15
Q

Calcifications in breast

A

3 types:

  1. Benign
  2. Artefact
  3. Suspicious
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16
Q

Benign calcs breat

Give examples

A
  1. Dermal calcs - appear in skin folds or anywhere women sweat. can confirm with tangenital projection*. They stay in the same place on CC and MLO views
  2. Vascular calcs
  3. Popcorn calcs - seen in **degenerating fibroadenoma
  4. Secretory Calcs - appear as rods or ‘dashes’. 10 - 20 years post menopausal and will point towards nipple.
  5. Eggshell calcs = think Fat necrosis. can be due to any kind of trauma. Lucent centre is buzzword. Appear as peripheral calcs. Seen in Oil cysts
  6. Dystrophic calcs = irregular in shape post radiation/trauma/surgery
  7. Rounded calcs - usually in both breasts scattered - if bilateral, and symmetric think of these.
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17
Q

Benign Calcs continued

A

Teacup or milk calcs

*Appear as teacup in shape on an ML view

Due to fluid fluid levels as a result of fibrocystic change*

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18
Q

Suspicious calcs in Breast

A

Fine pleomorphic and fine linear branching are most suspicious for malignancy with FIne linear branching being the worst

Makes DCIS more suspicious

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19
Q

What is Mondor Disease?

Benign

A

Essential a thrombosed vein in breast

Treat with NSAIDS and warm compress

No anticoags

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20
Q

Name 5 fat containing lesions of the breast?

A
  1. Hamartoma - ‘breast within a breast’ hard to see on US
  2. Galactocele - fluid fluid levels in lactating women
  3. Oil cyst - can have peripheral egg shell calcs (can be post surgery/trauma/random)
  4. Lipoma - enlargement is criteria for biopsy
  5. Intramammary lymph node - often located along pectoral muscle
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21
Q

Fibroadenoma

What are features?

What age group?

A

Most common palpable mass in young women (15-25 years, rarely over 50)

Oval, well circumscribed hypoechoic mass with central HYPERechoic band

T2 bright with type 1 progressive enhancement

If seen in an older patient - can have popcorn calcs

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22
Q

What is Phyllodes?

Solid mass containing cystic components and posterior acoustic enhancement

A

Fast growing breast mass

Think of this when you see a mass that looks like a fibroadenoma in an older patient

-risk of malignant degeneration and can metastasize to lungs
-haematogenous mets (not via lymphatics therefore don’t need to sample sentinel nodes)

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23
Q

Invasive ductal carcinoma

What are appearances?

A

Most common aggressive breast cancer

Arises in ducts but invades surrounding tissues and metastasizes

-spiculated irregular mass
-pleomorphic calcifications
-posterior acoustic shadowing on US

Invasive Ductal NOS (not otherwise specified) is most common breast cancer. NOS is where there is no distinguishing histological features.

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24
Q

Invasive Ductal carcinoma subtypes

A
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25
Q

What is multifocal vs mutlicentric Breast Ca?

A

Mutifocal = multiple primaries in same quadrant

Mutlicentric = multiple primaries in different quadrants

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26
Q

Ductal carcinoma in situ

What are features?

Which is most aggressive type?

A

This is the earliest form of breast cancer

Confined to the ducts
-therefore it has not extended into the parenchyma or lymphatics yet and cannot met

Histologist divide into Comedo and non-comedo type: **Comedo type is most aggressive **

**Most common ultrasound appearance **= microlobulated mildly hypoechoic mass with ductal extension, and normal acoustic transmission

-10% of DCIS on imaging may have an invasive component at the time biopsy is done
* 25% of DCIS on core biopsy may have an invasive component on surgical excision.
* 8% of DCIS will present as a mass without calcifications

Possible Q
-non mass enhancement on MRI
-multiple intraductal masses on galactography

27
Q

Pagets Disease of the Nippple

What is it assc with?

Does skin involvment confer T4?

A

Essentially a carcinoma of the nipple

Mean age is patient in their 60’s

**Assocaited with high grade DCIS in 97% cases
**Wedge biopsy should be done on any nipple/areolar lesion that DOESNT resolve with topical tx

Pagets is NOT T4 (skin involvement does not upgrade it)

28
Q

What is typical appearance of invasive lobular carcinoma?

A

2nd most common cancer

Ill defined area of shadowing on US

-can be bilateral and multicentric
-can cause breast shrinkage or loss of compressibility
-older population

29
Q

Inflammatory Breast Cancer

What are features?

A

Skin thickening, red breast, swollen

REMEMBER - mastitis is ONLY seen in breastfeeding women so always think of cancer in a non-breastfeeding woman with red swollen breast

Also, inflammatory changes in inflamm breast cancer can improve with antibiotics so dont be fooled and dismiss

If incomplete response to antibiotics within 1-2 weeks - suspect IBC

MRI is best modality for detecting primary lesion

30
Q

5 lesions that should be excised

A
31
Q

Primary breast lymphome is most commonly of which subtype?

A

Non-hodgkins

32
Q

What does architectural distorion appear like when compared to summation?

A

Architectural distorion will appear as radiating lines to a single point (summation will be lines that continue past eachother)

33
Q

Suspicious signs for axillary lymph nodes?

A
  1. Cortical thickness >2.3mm
  2. Loss of fatty hilum (most specific sign)
  3. Irregular outer margins
34
Q

What type of breast pathology do men NOT get?

A

No branching ducts or lobules therefore DONT GET

  1. Fibroadenomas
  2. Cysts
  3. Lobular carcinomas
35
Q

What rea the features of gynaecomastia in a man?

4 things

Name atypical and concerning features?

A
  1. Flame shaped - fans inwards from behind nipple
  2. Behind nipple
  3. Bilateral but asymmetric
  4. Can be painful

What are atypical features?

-Not behind nipple
-Calcification

36
Q

Male breast cancer

What is usual type?

A

Lump behind nipple is most common presentation

Average age is 70 years
Assc with alcoholism, klinefelters, cirrhosis

Invasive Ductal Carcinoma - NOS is most common type

Classic location is near the nipple
-abnormal lymph nodes
-calcifications (tend to be coarse)
-looks like breast cancer

37
Q

What are the 2 types of breast implant?

A
  1. Subpectoral - behind pec major and minor
  2. Subglandular - behind glandular tissue but anterior to pec muscles
38
Q

What are the different types of implant rupture?

A

Intracapsular and Extracapsular rupture

Once inserted - the body forms a fibrous capsule around the ‘foreign’ **SILICONE **breast implant

Intracapsular Rupture: when there is a rupture of the shell of the silicone implant and it doesnt’ extend outwith the fibrous capsule. Breast and implant usually keep shape.
-creates linguine sign on MRI

Extracapsular rupture: when rupture extends outwith the fibrous capsule. Implant loses shape. Snowstorm appearance on US

Can NOT have intracapsular rupture with saline implant - just extracapsular

39
Q

Are implants a contraindication for core needble biopsy?

A

NO

Just take care, especially with saline implants

40
Q

What is best MRI sequence for evaluating silicon implants and rupture?

A

T2 Fat sat

41
Q

Name 3 complications of having implants?

A
  1. Fibrous capsule contracture - where fibrous capsule contracts causing deformity. Can be seen in both silicon and saline, however more common in silicon
  2. Gel Bleed - silicon molecules can pass throught semipermeable membrane and be seen in axillary nodes (does NOT mean there is a rupture)
  3. Rupture - can see saline rupture on mammo. Silicon rupture seen on MRI

You CANNOT have isolated EXTRACAPSULAR rupture

42
Q

What is a mimic for breast implant rupture?

How to differentiate?

A

Radial folds

These are normal infoldings of the silicone shell.

They will always connect with outer silicone shell

43
Q

What are timeframes for tumour recurrence?

A

Usually between 1 - 7 years

4 years is peak time

Being Pre-meopausal increases risk

-Residual calcs are a bad sign
-Benign calcs occure early within 2 years
-Agressive calcs appear 4 years on usually

44
Q

What are the 2 main appearances of the breast post radiotherapy?

A
  1. Skin thickening
  2. Trabecular thickening
45
Q

What is diagnosis in patient presenting 6 years post breast conservation surgery/radiotherapy with red plaques or skin nodules?

A

Secondary Angiosarcoma

46
Q

What is breast conserving surgery?

A

Surgery to remove tumour and some surrounding tissue but not the breast itself
-some nodes can be removed
-some of chest wall can be removed if involved

T4 is invasive cancer involving:
-chest wall fixation
-skin involvement
-inflammatory breast ca

NOT Pagets of nipple

47
Q

What are contraindications to breast conserving surgery?

A
  1. Inflammatory cancer
  2. Large cancer relative to breast size
  3. Multicentric
  4. Prior radioation to same breast
  5. Any contrainfication to radiotherapy
48
Q

What is most common met to the breast?

A

Melanoma

49
Q

Main uses for MRI in breast?

A
  1. High risk screening
  2. Look for rupture
  3. Axillary mets with unknown primary
50
Q

Who gets high risk screening?

A

People with a lifetime risk greater than 20 - 25%

Use Tyrer-Cuzick model to calculate (not Gail)

51
Q

T2 bright lesions in breast

Are they usually benign or malignant?

A

T2 bright on MR are usually benign:
-fibroadenoma
-cysts
-fat necrosis

Exception is Mucinous Colloid Cancer which is malignant

52
Q

What is single most predictive feature of malignancy?

A

Spiculated margins

Of note:
-more exposure to oestrogen = increased risk of breast cancer

53
Q

Syndromes assocaited with Breast Cancer

A
54
Q

Breast Trivia

A
55
Q

What is the appearance of a radial scar?

A

Lesion with a stellate appearance and central lucency

56
Q

Best time to perform Breast MRI?

A

Anything that incorporates Day 10 of the cycle

57
Q

Best time to do MRI BReast

A
  1. 7 - 20 days after beginning of cycle
  2. 6 months after open biopsy
  3. 12 months
58
Q

Breast Abscess MRI findings?

A

MRI - Low T1, high T2, high STIR

Peripheral enhancement

(Chronic abscess may display high T1)

59
Q

Papilloma of breast

A
60
Q

Stellate lesion in RUO of the breast with central lucency

What is it?

A

Radial scar

61
Q

Loculated lesion with smooth margins and halo sign of low attenuation

What is it?

A

Fibroadenoma

Also can have popcorn calcifications

62
Q

Lobulated hypoechoic mass with ill defined borders and posterior acoustic enhancement in a 55 year old?

A

Phyllodes tumour

63
Q

HYPERechoic margins in a breast mass - what is significance?

A

Malignant