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Pathophysiology > RAAS > Flashcards

RAAS Flashcards

1
Q

When does RAAS get activated?

A

Blood volume drops and bp drops

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2
Q

What is the purpose of RAAS?

A

Increase blood volume and bp

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3
Q

What is the order of RAAS?

A

Renin, angiotensin, aldosterone

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4
Q

How many nephrons per kidney?

A

1 million

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5
Q

Where are the nephrons in the kidney?

A

Cortex

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6
Q

Does the afferent arteriole bring blood in or out of glomerulus?

A

in

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7
Q

Does the efferent arteriole bring blood in or out of glomerulus?

A

out

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8
Q

How much blood and filtrate does the kidneys filter each minute?

A

120mL

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9
Q

How much filtrate is produced each day?

A

180 liters

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10
Q

How much do we pee each day?

A

1.8L

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11
Q

Where is renin released?

A

Afferent arteriole

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12
Q

Is renin a hormone or enzyme?

A

enzyme

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13
Q

What cells release renin (2 names)?

A

Juxtaglomerular cells or Granular cells

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14
Q

How do the cells know if blood vol has dropped?

A

baroreceptors

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15
Q

Which cells in descending convoluted tubule measure concentration of Na?

A

Macula densa cells

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16
Q

What are the 3 reasons Renin can be released?

A

1) Decrease BP in afferent arteriole
2) Decrease Na in DCT
3) Increased SNS innervation

17
Q

What protein does the liver store?

A

Angiotensinogen

18
Q

What does renin and Angiotensinogen make?

A

angiotensin 1

19
Q

Where does Angiotensin Converting Enzyme come from?

A

lungs

20
Q

What does ACE + angiotensin 1 make?

A

angiotensin 2

21
Q

What does Angiotensin 2 do?

A

1) Generalized vasoconstrictor -> increases BP
2) Constricts efferent arteriole
3) release aldosterone
4) release ADH

22
Q

What does aldosterone do?

A

1) increases Na reabsorption
2) increases Blood volume
3) increase BP

23
Q

Where is aldosterone released?

A

Adrenal gland

24
Q

What does antidiuretic hormone do?

A

1) increase water reabsorption
2) increased blood volume
3) increased BP

25
Q

Where is Antidiuretic hormone released?

A

posterior pituitary gland

26
Q

What happens when the efferent arteriole is constricted?

A

increased GFR

Pathophysiology (6 decks)

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