Bone path 2 Flashcards
What is an osteodystrophy? Give examples.
Any condition in which there is weakening of bone, often associated with abnormal Ca2+ metabolism which results in increased risk of pathological fractures.
Examples:
Classical osteodystrophies
- Rickets and osteomalacia
- Fibrous osteodystrophy
- Osteopaenua/osteoporosis
Toxic osteodystrophies
- Fluorine toxicity - fluorosis
- lead toxicity
What is an osteodystrophy? Give examples.
Any condition in which there is weakening of bone, often associated with abnormal Ca2+ metabolism which results in increased risk of pathological fractures.
Examples:
Classical osteodystrophies
- Rickets and osteomalacia
- Fibrous osteodystrophy
- Osteopaenua/osteoporosis
Toxic osteodystrophies
- Fluorine toxicity - fluorosis
- lead toxicity
Can fully grown animals develop rickets?
No, only growing animals can develop rickets.
What are the nutritional causes of osteopaenia/osteoporosis?
- Starvation – most common in grazing animals
- Calcium deficiency – seldom occurs naturally. Inadequate Ca2+ supplementation of lactating gilts
- Phosphorus deficiency–more likely to cause rickets/osteomalacia Osteoporosis secondary to anorexia in P-deficient animals
- Copper deficiency - Cu is component of lysyl oxidase -required for cross linkage of collagen. Impaired cross linkage → increased fragility of bone (+/-cartilage). Also interferes with osteoblastic activity –lesion resembles scurvy histologically. Focal thickening of physes –resembles rickets. Predisposes to osteochondrosis in deer
What is osteopetrosis?
- Inherited defect in osteoclastic bone resorption -> solid bone with no marrow cavity
- autosomal recessive inheritance
- Reported in angus and simmental breeds of cattle, polypay lambs
- Bones are more dense than normal but have reduce breaking strength
What would you expect to see in osteogenesis imperfecta?
- Excessive bone fragility
- important disease of humans and rare in animals
