Immunoglobulins

Question 1

Which immunoglobulin is released into secretions?

Answer 1

IgA

Question 2

IgA is secreted as a _______ connected by a J chain

Answer 2

dimer

Question 3

_____ provides immunity at mucus membranes

Answer 3

IgA

Question 4

_______ protects against giardia

Answer 4

IgA

Question 5

_______ is produced in the GI tract at Peyer’s patches and airways

Answer 5

IgA

Question 6

Selective IgA deficiency causes recurrent….

Answer 6

GI and sinopulmonary infections

Question 7

_____ is the most abundant antibody in serum

Answer 7

IgG

Question 8

The slower production of _____ relative to IgM is due to the need for B cell class switching

Answer 8

IgG

Question 9

______ crosses the placenta

Answer 9

IgG

Question 10

______ fixes classical complement

Answer 10

IgG and IgM

Question 11

____ and ____ bind to C1 to being classical complement activation

Answer 11

IgG and IgM

Question 12

Opsonizes material for phagocytosis

Answer 12

IgG

Question 13

FcR region on phagocytes recognize ________ of IgG

Answer 13

Fc region

Question 14

______ neutralizes bacterial toxins and viruses

Answer 14

IgG

Question 15

Default antibody produced without class switching

Answer 15

IgM

Question 16

Defects in class switching lead to

Answer 16

Hyper IgM syndrome

Question 17

Produced immediately in response to a new antigen

Answer 17

IgM

Question 18

circulates as a pentamer

Answer 18

IgM

Question 19

can IgM cross the placenta?

Answer 19

No, too large

Question 20

binds to antigens on parasites and allergens

Answer 20

IgE

Question 21

mediates defense against parasites

Answer 21

IgE

Question 22

mediates allergic reactions/anaphylaxis

Answer 22

IgE

Question 23

mediates Type I HSR

Answer 23

IgE

Question 24

FcR of bound IgE is recognized by

Answer 24

mast cells and basophils

Question 25

IgE crosslinking to releases ______

Answer 25

histamine

Question 26

lowest concentration in serum

Answer 26

IgE

Question 27

When the Fc regions of IgE is bound by eosinophils, what is released?

Answer 27

major basic protein

Question 28

unclear function

Answer 28

IgD