Actinobacillus lignieresii

Question 1

hosts

Answer 1

cattle
sheep

Question 2

location

Answer 2

commensal of oral cavity

Question 3

what required for initial isolation

Answer 3

serum or blood and CO2

Question 4

what forms under chronic conditions
why

Answer 4

granuloma formation
because host can’t clear organism

Question 5

disease

Answer 5

actinobacillosis – wooden tongue

Question 6

lesions of wooden tongue

Answer 6

tumor like lesions of tongue and oral cavity that ulcerate
bacteria can spread to internal organs and skin after ulceration

Question 7

virulence

Answer 7

LPS
RTX exotoxin (weak)
capable of disseminating
resistance to host defense – chronic granulomatous inflammation

Question 8

vaccination

Answer 8

live vaccine expected to be optimal – none commercially available
bacterin used experimentally

Question 9

effects of experimental bacterin

Answer 9

reduced relapse
prevented new cases

Question 10

control

Answer 10

disease is sporadic, prevented by good management

Question 11

treatment

Answer 11

sodium/potassium iodide IV (70mg/kg of 10-20% solution) or in local lesions effectively stop acute signs

Question 12

treatment and going to slaughter

Answer 12

treatment with sodium/potassium iodide discouraged if going to slaughter

Question 13

other treatments

Answer 13

antibiotics – streptomycin
prevent feeding coarse feedstuffs – self inoculation of buccal epithelium