Neuro development Flashcards
describe the stages of neurogenesis at day 18
formation of the notochord at the midline
neural plate develops from overlying ectoderm - neuroectoderm
by day 20 of neurogenesis what has developed
neural crest
neural floor
where is the floorplate located
above the notochord
describe the stages of neurogenesis at days 22 and 24
neural plate folds inwards
the neural plate closes:
closes at the roofplate neural crest cells
in neurogenesis what does each part of neurogenesis cell become
anterior end - brain
neural tube near somites - spinal cord
neural crest - major components of PNS
lumen of the tube - ventricles (CSF)
where does the high degree of patterning occur and by what
neural tube
morphogens
what occurs out of anterior-posterior patterning
proliferation and segmentation generate the early spinal cord and 3 primary vesicles:
brainstem
midbrain
forebrain
what are Hox genes
family of transcription factors
establish segmentation along anterior-posterior axis
how do we know that cell fate can be induced
tissue from pigmented to non-pigmented amphibian embryo
secondary axis developed, mixed origins
transplanted cells instructed host cells
what happens if there is a lack of Shh
optic vesicles are generated on the dorsal side
leads to loss of ventral identity
cyclopia
what and where are neural precursor cells
neuroepithelial progenitor cells
neural tube
what do neural precursor cells form
the ventricular zone
what connects the ventricular and pial surface
radial glia
how do neural precursors divide and where and what does it produce
asymetrically
ventricular zone
generates new progenitors and postmitotic neuroblasts
where is the ventricular zone
the inner most layer of the neural tube
