Part K: Lecture 44

Question 1

unbalanced rearrangements result

Answer 1

decrease in health (not enough proteins)

Question 2

4 types of unbalanced rearrangements

Answer 2

terminal deletion
interstitial deletion
tandem duplication
insertional duplication

Question 3

balanced rearrangements result? why?

Answer 3

decrease in fertility
crossover of inverted region in heterozygous person –> unbalanced gametes

Question 4

4 types of balanced rearrangements

Answer 4

pericentric inversion
paracentric inversion
reciprocal translocation
robertsonian translocation

Question 5

homozygous for inv (9) karyotype

Answer 5

46,XX,inv (9), inv (9)

Question 6

WT chr + _____ = chr rear.

Answer 6

Crossover in wrong place

Question 7

balanced genotype + _____ = unbalanced genotype

Answer 7

Crossover in correct place

Question 8

translocation from chr 9 to 22 karyotype

Answer 8

translocation(9;22)(q34;q11)

Question 9

translocation chr is identified as ____ if it has the centromere of chr 9(#)

Answer 9

derivative (ex. der(9))

Question 10

evolution of genes

Answer 10

essential gene is duplicated (chr. rearrangement)
1st gene retains org. function
2nd gene mutates into nonfunctional pseudogene or new gene (ex. hemoglobin)