RIckets

Question 1

causes of rickets 5

Answer 1

vit D deficiency

calcium deficiency

Hypophosphataemic
-vit D resistant

hypophosphatasia

vit D dependent rickets

Question 2

causes of vit D defiiceicny rickets 2

Answer 2

lack of light

dietary deficeicnt in vit D

Question 3

causes of calcium deificent rickets 2

Answer 3

reduced aborpstion

-coeliac

-IBD

Question 4

cause of hypophosphataemic (vit D resisitant) rickets 1

-where is phosphate reaborated in the kidneys

-what is reabsorption of phosphate dependent on

Answer 4

imparited. resorbtion of phosphate

proximal renal tubules

parathormone (PTH)

Question 5

types of vit d dependent ricket s 2

Answer 5

type 1 defect in renal-1 hydrolase

type 2 end organ unresponsiveness to 1,25 vit D3

Question 6

clinical features of rickets

Answer 6

bone tenderness,

susceptibility for bone fractures, particularly greenstick fractures

soft, thinned skull bones – a condition known as craniotabes

skull bossing may be present and a delayed closure of the fontanelles.

bowed legs

thickened ankles and wrists;

knock knees

Spinal curvatures of kyphoscoliosis or lumbar lordosis The pelvic bones may be deformed.

A condition known as rachitic rosary can result as the thickening caused by nodules forming on the costochondral joints. This appears as a visible bump in the middle of each rib in a line on each side of the body. This somewhat resembles a rosary, giving rise to its name.

The deformity of a pigeon chest[10] may result in the presence of Harrison’s groove.

Hypocalcemia, a low level of calcium in the blood can result in tetany – uncontrolled muscle spasms. Dental problems can also arise.[10]