paeidiatric ortho antibodies

Question 1

state 4 muscle enzymes 4

Answer 1

creatitine kinase

LDH

AST

ALT

Question 2

when are muslce enzymes extremely high

Answer 2

muscular dystorphies (10,000-80,000)

Question 3

when are muscle enzymes moderatley raised

Answer 3

inflammatory muscle disease

Question 4

use of rheumatoid factor in paediatric ortho

Answer 4

can be raised due toa numebr of inflammtory stimuli

-can be transiently raised follwoing infection
-rarely psitive or important in childhood arhtitis

Question 5

what is used in the place of rhuematoid factors now ot check fo rheumatology

Answer 5

anti-CCP

Question 6

prescne of antinuclear antiboides (ANA)

Answer 6

found in 5% of normal healthy children

-negative in majority fo children with JIA

Question 7

precalence of
HLA B27 in healthy population

Answer 7

10%

Question 8

what conditions are HLA B27 strongly assocaited with and there percentage prevalence 6

Answer 8

inter-related group disorders (seronegative disorders)
-psoratic arthropathy (20%)
-ankylosing spondylitis (95%)
-enthesitis related arthitis (95%)
-IBD (50%)
-Reiters syndrome (reactive arthitis) (80%)
-anterior uvveitis (50%)§