rheumatic fever

Question 1

define rheumatic fever

Answer 1

develops follwoing an immunological reaction to a recent (2-4 weeks ago) Streptococcus pyogenes infection

Question 2

basic pathophys of rheumatic fever

Answer 2

streptococcus pyogense infection-> actiavtion of inate immune system

B and T cells produce IgG and IgM antibodies and CD4+ T cells are activated

type II hyperseneitivity reaction occurs

causes clinical feautes of rheumatic fever

Question 3

diagnostic criteria for rheumatic fever

Answer 3

evidence of recent streptococcal infection and 2 major or 1 major and 2 minor symptoms

Question 4

major criteria for rheumatic fever 5

Answer 4

erythema marginatum

sydenhams chorea

polyarhtitis

carditis and valvulaitis

subcutaneous nodules

Question 5

minor criteria for rheumatic fever 4

Answer 5

raised ESR or CRP

pyreixa

arthralgia

porlonged PR interval

Question 6

managment of rheumatic fever 2

Answer 6

oral penicillin V

NSAIDs (first line )

treat complications