Leukaemia

Question 1

only known cause of leukaemia

Answer 1

ionsiing radiation

Question 2

genetic condtions presdisposing to leukaemia 2

Answer 2

downs

Fanconis anaemia

Question 3

most common leukaemia in chidrne

Answer 3

acute lymphoblastic leukaemia

Question 4

presentation of leukaemia 7

Answer 4

bone marrow failure

bone pain/limp

lymphadenopathy

hepatosplenomegaly

testicular enlargement

cranial nerve palsies

menigism

Question 5

features of bone marrow failure 6

Answer 5

aneamia
-pallor
-dyspnoea

low WCC
-increased infections

low platelets
-bruising, petechiae, epistaxis

Question 6

diagnosis of leukaemia

Answer 6

FBC]

blood film

BM aspiratee

LP

coag

U&Es

LDH

CXR

Question 7

poor prognostic indicators for leukaemia 6

Answer 7

age <1 or >10

male

T cell lineage

WCC at presenation >50x10^9

chormosomal abnormalites -philadelphia chromosome t(9,22)

failure to rapdily respond to induction chemotherapy

Question 8

treatment for leukaemia

Answer 8

multi drug chemcotherapy

radiotherapy

bone marow transplants