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CP Test 1 > Autonomic Drugs -First Aid Reference > Flashcards

Autonomic Drugs -First Aid Reference Flashcards

1
Q

name the adrenergic receptor

located in:
* vascular smooth muscle
* visceral smooth muscle

A

a1

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2
Q

name the adrenergic receptor

effects:
* vasconstriction
* smooth muscle contraction

A

a1

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3
Q

name the adrenergic receptor

location:
* presynaptic terminals
* salivary glands

A

a2

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4
Q

name the adrenergic receptor

effect:
inhibition of neurotransmitter release

A

a2

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5
Q

name the adrenergic receptor

location:
* heart
* kidney

A

b1

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6
Q

name the adrenergic receptor

  • increase heart rate
  • increase renin secretion

effects

A

b1

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7
Q

name the adrenergic receptor

location:
* bronchioles
* cardiac muscle
* liver
* visceral smooth muscle

A

b2

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8
Q

name the adrenergic receptor

effect:
* bronchodilation
* increase HR and contractility
* inhibition of insulin secretion
* vasodilation

A

b2

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9
Q

name the adrenergic receptor

location:
adipose

A

b3

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10
Q

name the adrenergic receptor

effect:
lipolysis

A

b3

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11
Q

name the adrenergic receptor

effect:
decrease heart rate and contractility

A

m2

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12
Q

name the adrenergic receptor

effect:
increase exocrine gland secretions
increase peristalsis
increase bladder contraction
bronchoconstriction
pupillary constriction

A

m3

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13
Q

indirect cholinergic agonists: carbamates

2

A
  • psysostigmine
  • neostigmine
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14
Q

increases ACh
used for:
* reversal of neuromuscular junction blockade
* post operative urinary retention

A

neostigmine

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15
Q
  • increases ACh
  • cross blood-brain barrier
  • antidote for anticholinergic toxicity
A

physostigmine

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16
Q
  • simple alcohol ester
  • very short half-life
  • increases ACh
  • historically used to dx MG
A

edrophonium

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17
Q
  • muscarinic antagonist
  • used in eye
  • produces mydriasis and cycloplegia
A

atropine

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18
Q
  • muscarinic antagonist
  • quaternary amine
  • used for COPD, asthma
A

ipratropium

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19
Q
  • muscarinic antagonist
  • affects CNS
  • used for motion sickness
  • tertiary amine
A

scopalamine

20
Q

direct sympathomimetics
increase HR
used for asthma/COPD

2

A

albuterol
salmeterol

21
Q

selectivity: albuterol and salmeterol

A

b2>b1

22
Q
  • direct sympathomimetic
  • decreases BP
  • increase HR
  • increase CO
  • inotrope
A

dobutamine

23
Q

selectivity: dobutamine

A

b1>b2, a

24
Q
  • direct sympathomimetic
  • increases BP at high doses
  • increase heart rate
  • increase CO
  • anaphylaxis, shock asthma, glaucoma
A

epinephrine

25
Q

selectivity: epinephrine

A

b>a

26
Q

epinephrine:
[…] effects predominate at high doses

A

alpha

27
Q

stronger effect at b2 than noepinephrine

A

epinephrine

28
Q
  • direct sympathomimetic
  • decrease BP (vasodilation)
  • increase HR
  • increase CO
  • nonselective
A

isoproterenol

29
Q

selectivity: isoproterenol

A

b1=b2

30
Q
  • direct sympathomimetic
  • increase BP
  • hypotension
  • septic shock
A

norepinephrine

31
Q

selectivity: norepinephrine

A

a1>a2>b1

32
Q
  • direct sympathomimetic
  • increase BP (vasocontriction)
  • decrease HR
  • decrease CO
  • hypotension
  • decongestant
  • mydriasis
A

phenylephrine

33
Q

selectivity: phenylephrine

A

a1>a2

34
Q
  • indirect sympathomimetic
  • reuptake inhibitor
  • releases stored catecholamines
A

amphetamine

35
Q
  • indirect sympathomimetic
  • reuptake inhibitor
  • vasocontriction
  • local anesthesia
  • mydriasis
A

cocaine

36
Q
  • indirect sympathomimetic
  • releases stored catecholamines
  • nasal decongestant
  • hypotension
A

ephedrine

37
Q
  • caution when giving with b-blockers
  • unopposed a1 activation will cause massive increase in BP
A

cocaine

38
Q

norepinephrine + isoproterenol

A

NE is a1 agonist (increased MAP + bradycardia)
isoproterenol is b2 agonist (vasodilation)

Net:
* mean decrease in MAP
* increased HR

39
Q
  • a2 agonist
  • hypertension in pregnancy
A

methyldopa

40
Q
  • nonselective alpha blocker
  • irreversible
  • used preop to prevent chatecholamine crisis
  • can cause orthostatic hypotension, relex tachy
A

phenoxybenzamine

41
Q
  • nonselective alpha blocker
  • reversible
  • can cause orthostatic hypotension, relex tachy
A

phentolamine

42
Q

a1 selective alpha blockers

A

prazosin
terazosin
doxazosin

43
Q

adverse effects of a1 selective alpha blockers

A

orthostatic hypotension
dizziness
headache

44
Q

b1 selective antagonists

A

atenolol
metoprolol

45
Q

nonselective antagonist beta blockers

B1=B2

A

nadolol
timolol
propranolol

46
Q

nonselective a and b antagonist

A

labetalol

CP Test 1 (16 decks)

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