Psychopharmacology Drug Classes Flashcards

1
Q

What are some of the most popular first generation (conventional/typical/neuroleptic) antipsychotic medications?

A
  • Chlorpromazine (Thorazine)
  • Haloperidol (Haldol)
  • Fluphenazine (Prolixin)
  • Perphenazine (Trilafon)

suffix -azine

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2
Q

What are some of the most popular second generation (atypical/novel) antipsychotic medications?

A
  • Clozapine (Clozaril)
  • Risperidone (Risperdal)
  • Olanzapine (Zyprexa)
  • Quetiapine (Seroquel)
  • Ziprasidone (Geodon)

suffix -pine or -done

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3
Q

True or False: The atypical antipsychotics are more effective at treating negative/social/cognitive psychotic symptoms than the typical antipsychotics.

A

False - There is no significant difference in effectiveness in treating negative symptoms; however, the atypical antipsychotics have fewer side effects, but usually cost more too.

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4
Q

Mechanism of action : antipsychotics?

A

Block DA receptors so that DA is taken back up so there will be LESS DA in the brain.

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5
Q

What other conditions might use antipsychotics?

A

Other psychotic disorders (Brief Psychotic, Schizoaffective); mania or mixed episodes of Bipolar; Delirium; Tourette’s; Autism; pervasive developmental disabilities; PTSD; Major Depression

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6
Q

What are the common side effects of antipsychotics?

A
  • Sedation
  • Drowsiness
  • Dizziness upon standing (orthostatic hypotension)
  • Anticholinergic effects (dry mouth, dry eyes)
  • Weight gain
  • Sexual dysfunction
  • Movement symptoms (Dystonia, Parkinsonism, Tardive Dyskinesia)
  • Metabolic adverse effects
  • Nueroleptic Malignant Syndrome, rare but lethal

Clozaril - associated with agranulocytosis which is a dangerously low white blood cell count, rare but lethal

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7
Q

What are some popular SSRIs?

A
  • Sertraline (Zoloft)
  • Fluoxetine (Prozac)
  • Paroxetine (Paxil)

suffix -ine

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8
Q

What are some popular SNRIs?

A
  • Venlafaxine (Effexor)

suffix -ine

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9
Q

What are some popular Tricyclic antidepressants?

A
  • Amitriptyline (Elavil)
  • Clomipramine (Anafranil)
  • Imipramine (Tofranil)

suffix -amine

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10
Q

What are some popular MAOIs?

A
  • Tranylcypromine (Parnate)
  • Phenelzine (Nardil)

suffix -ine

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11
Q

What are some popular atypical/other classified antidepressants?

A
  • Bupropion (Wellbutrin) - works predominately on DA
  • Mirtazapine (Remeron)
  • Trazodone (Desyrel)

be careful not to lump Mirtazapine or Trazodone into antispsychotics

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12
Q

Which are the most dangerous antidepressant class?

A

Tricyclics

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13
Q

Which antidepressant class has dangerous interactions with food and medications?

A

MAOIs

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14
Q

Mechanism of Action : antidepressants?

A

Most block re-uptake of 5HT or NE so there will be MORE in the brain.

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15
Q

What are the common side effects of SSRIs?

A
  • Headaches
  • Insomnia
  • GI problems
  • Sexual dysfunction
  • Suicidal thinking in kids and teens
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16
Q

What are the common side effects of Tricyclics?

A
  • Severe Anticholinergic effects
  • Risk of Heart Disease, HBP, Seizure
  • Lethality of overdose
  • Sedation
  • Weight gain
  • Nausea
  • Sexual dysfunction
17
Q

What are the common side effects of MAOIs?

A
  • Tyramine induced hypertensive crisis (no pickles, cheese, sausage, wine, etc.)
  • Potential for Serotonin Syndrome
  • Lethality of overdose
  • Weight gain
  • Insomnia
  • Sexual dysfunction
  • Dizziness upon standing (orthostatic hypotension)
18
Q

What are some of the most popular benzodiazepines?

A
  • Alprazolam (Xanax)
  • Clonazepam (Klonopin)
  • Diazepam (Valium)
  • Lorazepam (Ativan)
  • Temazepam (Restoril)

suffix -pam or -lam

19
Q

What are some of the most popular non-benzodiazepines for sedative/hypnotic and anxiolytic purposes?

A
  • Buspirone (Buspar)
  • Zolpidem (Ambien)
  • Zaleplon (Sonata)
20
Q

What are some popular beta blockers?

A
  • Propranolol (Inderal)

suffix -lol

21
Q

What happens to your sleep when you stop taking a benzodiazepine?

A

Rebound insomnia (due to REM rebound and disrupted sleep cycle)

22
Q

What are the common side effects of benzodiazepines?

A
  • Physiological or psychological dependence
  • Tolerance & cross tolerance with alcohol
  • Fatal in overdose with alcohol
  • Abrupt withdrawal can be fatal
  • Higher risk with older adults
  • Drowsiness
  • Dizziness
  • Problems with coordination
  • Nightmares
23
Q

What are the common side effects of beta blockers?

A
  • Sexual dysfunction
  • Fatigue
  • Shortness of breath
  • Dizziness
  • Difficulty sleeping
  • Nightmares
24
Q

What are some popular mood stabilizers?

A
  • Lithium
  • Anticonvulsants
    - Carbamazepine (Tegretol)
    - Sodium valproate (Depokote)
    - Gabapentin (Neurontin)
25
Q

What are some contraindications for lithium?

A
  • Likely compliance issues
  • Pre-existing heart, thyroid, or kidney disease
  • Pregnancy
26
Q

What are the common side effects for lithium?

A
  • Have to monitor blood levels, thyroid, and kidney problems
  • Possibility for lithium toxicity (looks like the flu)
  • Fine hand tremor
  • Weight gain
  • GI problems
  • Sedation
  • Excessive thirst and urination
27
Q

What are the common side effects for anticonvulsants?

A
  • Drowsiness
  • Headache
  • Diarrhea
  • Suicidal thinking
28
Q

What are some popular stimulants?

A
  • Methylphenidate (Ritalin, Concerta)
  • Adderral
29
Q

What is the non-stimulant medication commonly used for ADHD?

A
  • Atomoxetine (Straterra)

SNRI approved for treatment of ADHD

30
Q

What are the common side effects of stimulants?

A
  • Loss of appetite
  • Insomnia
  • Irritability
  • GI problems
  • Temporary growth suppression in kids
  • Could trigger tic disorders
  • Psychological/physical dependence
  • Withdrawal effects but overdose is rarely lethal