Synthetic glucocorticoids

Question 1

Fludrocortisone

Answer 1

9 alpha- Fluorine

Stronger mineralocorticoid activity than glucocorticoid activity

Side effect: high sodium retention leading to edema

use: mineralocorticoid replacement therapy

Question 2

Prednisone/Prednisolone

Answer 2

Contain a double bond between C1 and C2

Potent glucocorticoid activity rather than mineralocorticoid activity

Can be converted reversibly by the 11B-hydroxysteroid dehydrogenase

Question 3

Methylpresnisolone

Answer 3

6 alpha- methyl

low mineralcorticoid activity

Question 4

Triamcinolone

Answer 4

9 alpha- Fluorine + 16 alpha -hydroxy

potent glucocorticoid activity rather than mineralocorticoid activity

increased hydrolipiphilicity, low oral bioavailability

Question 5

Dexamethasone

Answer 5

16 alpha- methyl

low mineralocorticoid activity

increase lipophilicity, increased stability, increased bioavailability

Question 6

Betamethasone

Answer 6

enantiomer of dexamethasone