SERM estrogens

Question 1

Tamoxifen

Answer 1

prodrug that acts as a partial agonist

Estrogenic:
agonist at endometrial cells–>bleeding
prevents osteoporosis
increase risk of thromboembolic events

Antiestrogenic: treats breast cancer

Question 2

Toremifene

Answer 2

structure like tamoxifen
treatment of advanced breast cancer

Question 3

Ospemifene

Answer 3

structure like toremifene
Use: treats dyspareunia in post-menopausal women

Question 4

Raloxifene & Bazedoxifene

Answer 4

Estrogenic:
prevents osteoporosis
decreases LDL levels
increases risk of blood clots

Antiestrogenic:
decreases risk of breast cancer
causes hot flashes

Question 5

Clomiphene

Answer 5

Use: stimulate ovulation in women with oligomenorrhea or amenorrhea by
increasing secretion of FSH and LH

Side Effect: multiple pregnancy

Question 6

Fulvestrant

Answer 6

Full antagonist (SERD)

treat breast cancer

used in patients that are resistant to tamoxifen