Inhaled glucocorticoids

Question 1

Triamcinolone acetonide

Answer 1

resistant to hydrolysis–>acetonide

high potency

Question 2

Beclomethasone dipropionate

Answer 2

rapidly hydrolyzed to 17-monopropionate

high potency

Question 3

Flunisolide

Answer 3

rapidly absorbed by nasal and lung tissue

rapid metabolism by the liver
- first pass
-minimal systemic effects

Question 4

Budesonide

Answer 4

1:1 mixture of epimer at 16,17 butyl acetal

low oral bioavailability

rapid metabolism by the liver
-first pass

Question 5

Mometasone furoate

Answer 5

high potent
rapid onset
rapid metabolism by the liver
-minimal systemic effect
-low oral bioavailability

Question 6

Fluticasone propionate

Answer 6

rapid metabolism by the liver
-inactivated by hydrolysis of thioester

highly lipophilic and insoluble
highly potent, poor absorption, low oral bioavailability