Case 2 - medications

Question 1

what is amoxicillin

Answer 1

is a penicillin derivative used for the treatment of infections caused by gram positive bacteria

Question 2

what is amoxicillin commonly used in combination with for the treatment of H pylori

Answer 2

omeprazole

Question 3

what is the mechanism of action of amoxicillin

Answer 3

competitively inhibits penicillin-binding protein 1
Penicillin bind proteins are responsible for glycotransferase and transpeptidase reactions that lead to cross-linking of D-alanine and D-aspartic acid in bacterial cell walls
Helicobactor pylori is an inhibitor - penicillin binding protein
Amoxicillin competitively inhibits penicillin binding proteins, leading to up regulation of autolytic enzymes and inhibition of cell wall synthesis

Question 4

what is clarithromycin

Answer 4

a macrolide antibiotic used for the treatment of a wide variety of bacterial infections

Question 5

what is clarithromycin derived orm

Answer 5

erythromycin

Question 6

what is the mechanism of action of clarithromycin

Answer 6

it inhibits bacterial synthesis by binding to the bacterial 505 ribosomal subunit

binding inhibits peptifyl transferase activity and interferes with amino acid translocation

Question 7

what is another combination of drugs that can be used to treat h pylori

Answer 7

H.pylori infection can also be treated using a combination of clarithromycin, vonoprazan and amoxicillin