Hep B

Question 1

what is Hep B virus?

Answer 1

double stranded DNA hepadnavirus

Question 2

how is hep B spread?

Answer 2

exposure to infected blood, body fluids or vertical transmission

Question 3

incubation period of Hep B?

Answer 3

6-20 weeks

Question 4

features of Hep B?

Answer 4

fever, jaundice and elevated liver trasnaminase

Question 5

complications of Hep B?

Answer 5

chronic hepatitis (ground glass hepatocytes)
hepatocellular carcinoma,
liver failure
glomerulonephritis
polyarteritis nodosa
cryoglobulinaemia (abnormal proteins in blood clump together in cold)

Question 6

what age are vaccines given for Hep B?

Answer 6

2,3 and 4 months

Question 7

what do you give in hep b vaccination?

Answer 7

HBsAG prepared from yeast cells

Question 8

response to vaccination Hep B?

Answer 8

more than 100- no further testing booster at 5 years
10-100- suboptimal response one additional vaccine dose
less than 10- not responding check for current or past infection. may require HBIG for protection

Question 9

management of Hep B?

Answer 9

pegylated interferon alpha first line to reduce viral replication
other medication: tenofovir, entecavir and telbivudine

Question 10

what would you see on Heb B serology?

Answer 10

HBsAg less than 6 months acute, more then chronic

AntiHBc- previous or current infection
igM anti-HB appears in acute infection IgG antiHBc persists

Question 11

HbeAg implies?

Answer 11

marker of infectivity